Histone acetylation in reproductive organs: Significance of histone deacetylase inhibitors in gene transcription

Hiroshi Uchida, Tetsuo Maruyama, Toru Arase, Masanori Ono, Takashi Nagashima, Hirotaka Masuda, Hironori Asada, Yasunori Yoshimura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Acetylation of histones is cooperatively regulated by two groups of enzymes, histone acetyltransferases and histone deacetylases. Histone acetylation status plays a fundamental role in the level of gene transcription; numerous studies have demonstrated that histone deacetylase inhibitors cause cell growth arrest, apoptosis, and differentiation in various cells including human mammary gland and endometrial cells by altering transcription of a small number of genes. A recent study has also shown that a highly acetylated histone status alters cell motility. After the present review of the published reports on the mechanisms underlying histone acetylation and in vitro effects of histone deacetylase inhibitors, we conclude that this class of agents may have potential not only as anticancer drugs, but also as inducers of differentiation and/or motility for benign gynecologic conditions such as endometriosis and disorders of endometrial differentiation and dysfunction.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalReproductive Medicine and Biology
Volume4
Issue number2
DOIs
Publication statusPublished - 2005 Jun

Fingerprint

Histone Deacetylase Inhibitors
Acetylation
Histones
Genes
Histone Acetyltransferases
Histone Deacetylases
Endometriosis
Human Mammary Glands
Cell Movement
Apoptosis
Enzymes
Growth
Pharmaceutical Preparations

Keywords

  • Histone acetylation
  • Histone deacetylase inhibitor
  • Suberoylanilide hydroxamic acid
  • Trixchostatin A

ASJC Scopus subject areas

  • Reproductive Medicine
  • Physiology

Cite this

Histone acetylation in reproductive organs : Significance of histone deacetylase inhibitors in gene transcription. / Uchida, Hiroshi; Maruyama, Tetsuo; Arase, Toru; Ono, Masanori; Nagashima, Takashi; Masuda, Hirotaka; Asada, Hironori; Yoshimura, Yasunori.

In: Reproductive Medicine and Biology, Vol. 4, No. 2, 06.2005, p. 115-122.

Research output: Contribution to journalArticle

Uchida, Hiroshi ; Maruyama, Tetsuo ; Arase, Toru ; Ono, Masanori ; Nagashima, Takashi ; Masuda, Hirotaka ; Asada, Hironori ; Yoshimura, Yasunori. / Histone acetylation in reproductive organs : Significance of histone deacetylase inhibitors in gene transcription. In: Reproductive Medicine and Biology. 2005 ; Vol. 4, No. 2. pp. 115-122.
@article{13f38ff4666f43c5971e7a12887d9d9a,
title = "Histone acetylation in reproductive organs: Significance of histone deacetylase inhibitors in gene transcription",
abstract = "Acetylation of histones is cooperatively regulated by two groups of enzymes, histone acetyltransferases and histone deacetylases. Histone acetylation status plays a fundamental role in the level of gene transcription; numerous studies have demonstrated that histone deacetylase inhibitors cause cell growth arrest, apoptosis, and differentiation in various cells including human mammary gland and endometrial cells by altering transcription of a small number of genes. A recent study has also shown that a highly acetylated histone status alters cell motility. After the present review of the published reports on the mechanisms underlying histone acetylation and in vitro effects of histone deacetylase inhibitors, we conclude that this class of agents may have potential not only as anticancer drugs, but also as inducers of differentiation and/or motility for benign gynecologic conditions such as endometriosis and disorders of endometrial differentiation and dysfunction.",
keywords = "Histone acetylation, Histone deacetylase inhibitor, Suberoylanilide hydroxamic acid, Trixchostatin A",
author = "Hiroshi Uchida and Tetsuo Maruyama and Toru Arase and Masanori Ono and Takashi Nagashima and Hirotaka Masuda and Hironori Asada and Yasunori Yoshimura",
year = "2005",
month = "6",
doi = "10.1111/j.1447-0578.2005.00101.x",
language = "English",
volume = "4",
pages = "115--122",
journal = "Reproductive Medicine and Biology",
issn = "1445-5781",
publisher = "Springer Japan",
number = "2",

}

TY - JOUR

T1 - Histone acetylation in reproductive organs

T2 - Significance of histone deacetylase inhibitors in gene transcription

AU - Uchida, Hiroshi

AU - Maruyama, Tetsuo

AU - Arase, Toru

AU - Ono, Masanori

AU - Nagashima, Takashi

AU - Masuda, Hirotaka

AU - Asada, Hironori

AU - Yoshimura, Yasunori

PY - 2005/6

Y1 - 2005/6

N2 - Acetylation of histones is cooperatively regulated by two groups of enzymes, histone acetyltransferases and histone deacetylases. Histone acetylation status plays a fundamental role in the level of gene transcription; numerous studies have demonstrated that histone deacetylase inhibitors cause cell growth arrest, apoptosis, and differentiation in various cells including human mammary gland and endometrial cells by altering transcription of a small number of genes. A recent study has also shown that a highly acetylated histone status alters cell motility. After the present review of the published reports on the mechanisms underlying histone acetylation and in vitro effects of histone deacetylase inhibitors, we conclude that this class of agents may have potential not only as anticancer drugs, but also as inducers of differentiation and/or motility for benign gynecologic conditions such as endometriosis and disorders of endometrial differentiation and dysfunction.

AB - Acetylation of histones is cooperatively regulated by two groups of enzymes, histone acetyltransferases and histone deacetylases. Histone acetylation status plays a fundamental role in the level of gene transcription; numerous studies have demonstrated that histone deacetylase inhibitors cause cell growth arrest, apoptosis, and differentiation in various cells including human mammary gland and endometrial cells by altering transcription of a small number of genes. A recent study has also shown that a highly acetylated histone status alters cell motility. After the present review of the published reports on the mechanisms underlying histone acetylation and in vitro effects of histone deacetylase inhibitors, we conclude that this class of agents may have potential not only as anticancer drugs, but also as inducers of differentiation and/or motility for benign gynecologic conditions such as endometriosis and disorders of endometrial differentiation and dysfunction.

KW - Histone acetylation

KW - Histone deacetylase inhibitor

KW - Suberoylanilide hydroxamic acid

KW - Trixchostatin A

UR - http://www.scopus.com/inward/record.url?scp=21344445065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21344445065&partnerID=8YFLogxK

U2 - 10.1111/j.1447-0578.2005.00101.x

DO - 10.1111/j.1447-0578.2005.00101.x

M3 - Article

AN - SCOPUS:21344445065

VL - 4

SP - 115

EP - 122

JO - Reproductive Medicine and Biology

JF - Reproductive Medicine and Biology

SN - 1445-5781

IS - 2

ER -