Histone acetylation in reproductive organs: Significance of histone deacetylase inhibitors in gene transcription

Hiroshi Uchida, Tetsuo Maruyama, Toru Arase, Masanori Ono, Takashi Nagashima, Hirotaka Masuda, Hironori Asada, Yasunori Yoshimura

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Acetylation of histones is cooperatively regulated by two groups of enzymes, histone acetyltransferases and histone deacetylases. Histone acetylation status plays a fundamental role in the level of gene transcription; numerous studies have demonstrated that histone deacetylase inhibitors cause cell growth arrest, apoptosis, and differentiation in various cells including human mammary gland and endometrial cells by altering transcription of a small number of genes. A recent study has also shown that a highly acetylated histone status alters cell motility. After the present review of the published reports on the mechanisms underlying histone acetylation and in vitro effects of histone deacetylase inhibitors, we conclude that this class of agents may have potential not only as anticancer drugs, but also as inducers of differentiation and/or motility for benign gynecologic conditions such as endometriosis and disorders of endometrial differentiation and dysfunction.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalReproductive Medicine and Biology
Volume4
Issue number2
DOIs
Publication statusPublished - 2005 Jun

Keywords

  • Histone acetylation
  • Histone deacetylase inhibitor
  • Suberoylanilide hydroxamic acid
  • Trixchostatin A

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

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