Histopathological insights into hair loss in Cronkhite-Canada syndrome

Diffuse anagen-telogen conversion precedes clinical hair loss progression

Emiko Watanabe-Okada, Toyoko Inazumi, Hidehiko Matsukawa, Manabu Ohyama

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cronkhite-Canada syndrome (CCS) is a rare disorder characterised by gastrointestinal polyposis and ectodermal changes, represented by extensive alopecia. Detailed histopathological investigations of alopecic lesions in two female CCS patients with severe hair loss revealed a marked increase in telogen hair follicles with no sign of loss or of the minaturisation or atrophy of hair follicle structures and the absence of inflammatory change, despite severe inflammation in the gastrointestinal tract. These findings suggested that hair regrowth can be expected without systemic corticosteroids, if they are not necessary for treatment of the gastrointestinal tract, and that anagen-telogen transition is an early event preceding clinical hair loss in CCS.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalAustralasian Journal of Dermatology
Volume55
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Intestinal Polyposis
Alopecia
Hair Follicle
Gastrointestinal Tract
Hair
Atrophy
Adrenal Cortex Hormones
Inflammation
Therapeutics

Keywords

  • Cronkhite-Canada syndrome
  • hair loss
  • histopathology
  • telogen

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Histopathological insights into hair loss in Cronkhite-Canada syndrome : Diffuse anagen-telogen conversion precedes clinical hair loss progression. / Watanabe-Okada, Emiko; Inazumi, Toyoko; Matsukawa, Hidehiko; Ohyama, Manabu.

In: Australasian Journal of Dermatology, Vol. 55, No. 2, 2014, p. 145-148.

Research output: Contribution to journalArticle

Watanabe-Okada, Emiko ; Inazumi, Toyoko ; Matsukawa, Hidehiko ; Ohyama, Manabu. / Histopathological insights into hair loss in Cronkhite-Canada syndrome : Diffuse anagen-telogen conversion precedes clinical hair loss progression. In: Australasian Journal of Dermatology. 2014 ; Vol. 55, No. 2. pp. 145-148.
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