Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan

Kouji Harada, Akio Koizumi, Norimitsu Saito, Kayoko Inoue, Takeo Yoshinaga, Chigusa Date, Shigeo Fujii, Noriyuki Hachiya, Iwao Hirosawa, Shigeki Koda, Yukinori Kusaka, Katsuyuki Murata, Kazuyuki Omae, Shinichiro Shimbo, Katsunobu Takenaka, Tatsuya Takeshita, Hidemi Todoriki, Yasuhiko Wada, Takao Watanabe, Masayuki Ikeda

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) have recently received attention due to their widespread contamination in the environment, as well as in wildlife and humans. We measured the PFOS and PFOA concentrations in historically recorded human serum samples at an age range between 20 and 59 years collected in Kyoto, 20 persons per each time point (n = 100), and also the PFOS and PFOA concentrations in human serum samples at an age range between 20 and 59 years from 10 locations throughout Japan (n = 200). The historical samples collected from 1983 to 1999 demonstrated that the PFOA concentrations in males and females from Kyoto have increased 4.4-fold and 4.3-fold at a rate of increase of 0.49 ng/ml/year and 0.42 ng/ml/year, respectively. In contrast, serum concentrations of PFOS reached a plateau in the late 1980s. There are also regional differences in both the PFOS and PFOA serum concentrations. The concentrations in serum [geometric mean (geometric standard deviation)] (ng/ml) in 2003-2004 ranged from 7.6(1.6) in the town of Matsuoka in Fukui prefecture to 27.8(1.6) in Kyoto city, and ranged from 2.3(1.5) in Matsuoka to 14.5(1.3) in Osaka city for PFOS and PFOA, respectively.

Original languageEnglish
Pages (from-to)293-301
Number of pages9
JournalChemosphere
Volume66
Issue number2
DOIs
Publication statusPublished - 2007 Jan

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perfluorooctanoic acid
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perfluorooctane sulfonic acid
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Keywords

  • Geographical difference
  • Long-term trend
  • Perfluorooctane sulfonate
  • Perfluorooctanoate
  • Serum

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)

Cite this

Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan. / Harada, Kouji; Koizumi, Akio; Saito, Norimitsu; Inoue, Kayoko; Yoshinaga, Takeo; Date, Chigusa; Fujii, Shigeo; Hachiya, Noriyuki; Hirosawa, Iwao; Koda, Shigeki; Kusaka, Yukinori; Murata, Katsuyuki; Omae, Kazuyuki; Shimbo, Shinichiro; Takenaka, Katsunobu; Takeshita, Tatsuya; Todoriki, Hidemi; Wada, Yasuhiko; Watanabe, Takao; Ikeda, Masayuki.

In: Chemosphere, Vol. 66, No. 2, 01.2007, p. 293-301.

Research output: Contribution to journalArticle

Harada, K, Koizumi, A, Saito, N, Inoue, K, Yoshinaga, T, Date, C, Fujii, S, Hachiya, N, Hirosawa, I, Koda, S, Kusaka, Y, Murata, K, Omae, K, Shimbo, S, Takenaka, K, Takeshita, T, Todoriki, H, Wada, Y, Watanabe, T & Ikeda, M 2007, 'Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan', Chemosphere, vol. 66, no. 2, pp. 293-301. https://doi.org/10.1016/j.chemosphere.2006.05.010
Harada, Kouji ; Koizumi, Akio ; Saito, Norimitsu ; Inoue, Kayoko ; Yoshinaga, Takeo ; Date, Chigusa ; Fujii, Shigeo ; Hachiya, Noriyuki ; Hirosawa, Iwao ; Koda, Shigeki ; Kusaka, Yukinori ; Murata, Katsuyuki ; Omae, Kazuyuki ; Shimbo, Shinichiro ; Takenaka, Katsunobu ; Takeshita, Tatsuya ; Todoriki, Hidemi ; Wada, Yasuhiko ; Watanabe, Takao ; Ikeda, Masayuki. / Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan. In: Chemosphere. 2007 ; Vol. 66, No. 2. pp. 293-301.
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abstract = "Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) have recently received attention due to their widespread contamination in the environment, as well as in wildlife and humans. We measured the PFOS and PFOA concentrations in historically recorded human serum samples at an age range between 20 and 59 years collected in Kyoto, 20 persons per each time point (n = 100), and also the PFOS and PFOA concentrations in human serum samples at an age range between 20 and 59 years from 10 locations throughout Japan (n = 200). The historical samples collected from 1983 to 1999 demonstrated that the PFOA concentrations in males and females from Kyoto have increased 4.4-fold and 4.3-fold at a rate of increase of 0.49 ng/ml/year and 0.42 ng/ml/year, respectively. In contrast, serum concentrations of PFOS reached a plateau in the late 1980s. There are also regional differences in both the PFOS and PFOA serum concentrations. The concentrations in serum [geometric mean (geometric standard deviation)] (ng/ml) in 2003-2004 ranged from 7.6(1.6) in the town of Matsuoka in Fukui prefecture to 27.8(1.6) in Kyoto city, and ranged from 2.3(1.5) in Matsuoka to 14.5(1.3) in Osaka city for PFOS and PFOA, respectively.",
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T1 - Historical and geographical aspects of the increasing perfluorooctanoate and perfluorooctane sulfonate contamination in human serum in Japan

AU - Harada, Kouji

AU - Koizumi, Akio

AU - Saito, Norimitsu

AU - Inoue, Kayoko

AU - Yoshinaga, Takeo

AU - Date, Chigusa

AU - Fujii, Shigeo

AU - Hachiya, Noriyuki

AU - Hirosawa, Iwao

AU - Koda, Shigeki

AU - Kusaka, Yukinori

AU - Murata, Katsuyuki

AU - Omae, Kazuyuki

AU - Shimbo, Shinichiro

AU - Takenaka, Katsunobu

AU - Takeshita, Tatsuya

AU - Todoriki, Hidemi

AU - Wada, Yasuhiko

AU - Watanabe, Takao

AU - Ikeda, Masayuki

PY - 2007/1

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N2 - Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) have recently received attention due to their widespread contamination in the environment, as well as in wildlife and humans. We measured the PFOS and PFOA concentrations in historically recorded human serum samples at an age range between 20 and 59 years collected in Kyoto, 20 persons per each time point (n = 100), and also the PFOS and PFOA concentrations in human serum samples at an age range between 20 and 59 years from 10 locations throughout Japan (n = 200). The historical samples collected from 1983 to 1999 demonstrated that the PFOA concentrations in males and females from Kyoto have increased 4.4-fold and 4.3-fold at a rate of increase of 0.49 ng/ml/year and 0.42 ng/ml/year, respectively. In contrast, serum concentrations of PFOS reached a plateau in the late 1980s. There are also regional differences in both the PFOS and PFOA serum concentrations. The concentrations in serum [geometric mean (geometric standard deviation)] (ng/ml) in 2003-2004 ranged from 7.6(1.6) in the town of Matsuoka in Fukui prefecture to 27.8(1.6) in Kyoto city, and ranged from 2.3(1.5) in Matsuoka to 14.5(1.3) in Osaka city for PFOS and PFOA, respectively.

AB - Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) have recently received attention due to their widespread contamination in the environment, as well as in wildlife and humans. We measured the PFOS and PFOA concentrations in historically recorded human serum samples at an age range between 20 and 59 years collected in Kyoto, 20 persons per each time point (n = 100), and also the PFOS and PFOA concentrations in human serum samples at an age range between 20 and 59 years from 10 locations throughout Japan (n = 200). The historical samples collected from 1983 to 1999 demonstrated that the PFOA concentrations in males and females from Kyoto have increased 4.4-fold and 4.3-fold at a rate of increase of 0.49 ng/ml/year and 0.42 ng/ml/year, respectively. In contrast, serum concentrations of PFOS reached a plateau in the late 1980s. There are also regional differences in both the PFOS and PFOA serum concentrations. The concentrations in serum [geometric mean (geometric standard deviation)] (ng/ml) in 2003-2004 ranged from 7.6(1.6) in the town of Matsuoka in Fukui prefecture to 27.8(1.6) in Kyoto city, and ranged from 2.3(1.5) in Matsuoka to 14.5(1.3) in Osaka city for PFOS and PFOA, respectively.

KW - Geographical difference

KW - Long-term trend

KW - Perfluorooctane sulfonate

KW - Perfluorooctanoate

KW - Serum

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