HIV-2 CRF01-AB: First circulating recombinant form of HIV-2

Shiro Ibe, Yoshiyuki Yokomaku, Teiichiro Shiino, Rie Tanaka, Junko Hattori, Seiichiro Fujisaki, Yasumasa Iwatani, Naoto Mamiya, Makoto Utsumi, Shingo Kato, Motohiro Hamaguchi, Wataru Sugiura

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Five HIV-2-seropositive cases were recently identified in Japan, outside the HIV-2 endemic area of West Africa. To clarify the molecular epidemiology of HIV-2 in Japan, we analyzed sequences of these cases in detail. Methods: HIV-2 genetic groups were determined by gag and env sequences. For suspected recombinant isolates, the genetic structure was determined by full-length genomic analyses. To understand the history and evolution of HIV-2 recombinant isolates, we estimated the time of most recent common ancestor by Bayesian Markov chain Monte Carlo method. Results: Three isolates were determined as recombinants of groups A and B, and their mosaic genome structures were identical with that of 7312A, a recombinant isolate reported in 1990 from Côte dIvoire. Our 3 isolates and 7312A fulfilled the criteria for determining a circulating recombinant form (CRF). These isolates were verified by the Los Alamos HIV sequence database as the first CRF of HIV-2, HIV-2 CRF01-AB. The mean time of most recent common ancestor of CRF01-AB was estimated as between 1964 and 1973, several decades after the estimated emergence of HIV-2. Conclusions: We recently identified HIV-2 CRF01-AB cases in Japan. This ectopic observation of the virus outside its original endemic area suggests an ongoing global spread of HIV-2 CRF01-AB.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume54
Issue number3
DOIs
Publication statusPublished - 2010 Jul 1

Fingerprint

HIV-2
Japan
Monte Carlo Method
Markov Chains
Western Africa
Molecular Epidemiology
Genetic Structures
History
Observation
HIV
Genome
Databases
Viruses

Keywords

  • circulating recombinant form
  • CRF01-AB
  • HIV-2
  • molecular epidemiology

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Ibe, S., Yokomaku, Y., Shiino, T., Tanaka, R., Hattori, J., Fujisaki, S., ... Sugiura, W. (2010). HIV-2 CRF01-AB: First circulating recombinant form of HIV-2. Journal of Acquired Immune Deficiency Syndromes, 54(3), 241-247. https://doi.org/10.1097/QAI.0b013e3181dc98c1

HIV-2 CRF01-AB : First circulating recombinant form of HIV-2. / Ibe, Shiro; Yokomaku, Yoshiyuki; Shiino, Teiichiro; Tanaka, Rie; Hattori, Junko; Fujisaki, Seiichiro; Iwatani, Yasumasa; Mamiya, Naoto; Utsumi, Makoto; Kato, Shingo; Hamaguchi, Motohiro; Sugiura, Wataru.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 54, No. 3, 01.07.2010, p. 241-247.

Research output: Contribution to journalArticle

Ibe, S, Yokomaku, Y, Shiino, T, Tanaka, R, Hattori, J, Fujisaki, S, Iwatani, Y, Mamiya, N, Utsumi, M, Kato, S, Hamaguchi, M & Sugiura, W 2010, 'HIV-2 CRF01-AB: First circulating recombinant form of HIV-2', Journal of Acquired Immune Deficiency Syndromes, vol. 54, no. 3, pp. 241-247. https://doi.org/10.1097/QAI.0b013e3181dc98c1
Ibe, Shiro ; Yokomaku, Yoshiyuki ; Shiino, Teiichiro ; Tanaka, Rie ; Hattori, Junko ; Fujisaki, Seiichiro ; Iwatani, Yasumasa ; Mamiya, Naoto ; Utsumi, Makoto ; Kato, Shingo ; Hamaguchi, Motohiro ; Sugiura, Wataru. / HIV-2 CRF01-AB : First circulating recombinant form of HIV-2. In: Journal of Acquired Immune Deficiency Syndromes. 2010 ; Vol. 54, No. 3. pp. 241-247.
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