HMW-adiponectin associates with triglyceride concentrations in type 1 diabetic patients

Chizuko Maruyama, Rieko Ishibashi, Risa Araki, Shino Koike, Hiroshi Hirose, Taro Maruyama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aim: The objective of this study was to investigate the relation between serum high molecular weight (HMW)-adiponectin concentration and fasting and postprandial blood glycemic and lipid parameters in type 1 diabetic patients. Methods: Type 1 diabetic patients treated with short-acting insulin analogs and healthy volunteers were recruited. The subjects were divided into two groups based on the mean HMW-adiponectin value of 12.2 mg/L: low HMW-adiponectin (men/women=7/2) and high HMW-adiponectin (men/ women=3/8). Blood samples were collected after an overnight fast, and 30-180 min after consuming white bread (B) or white bread with butter (BB). Results: Type 1 diabetic patients with high HMW-adiponectin had lower triglyceride and remnant like particle (RLP)-triglyceride concentrations than those with low HMW-adiponectin (p<0.01), and had a higher lipoprotein lipase mass (p<0.01) than healthy subjects (men/women=8/ 6). After B and BB meals, type 1 diabetic patients with high HMW-adiponectin consistently had lower triglyceride and RLP-triglyceride concentrations for up to 180 min than those with low HMW-adiponectin (p<0.01); however, apoB48 did not differ between these two groups. Fasting and postprandial plasma glucose were higher in both diabetic groups than in healthy subjects (p<0.001), with no significant difference between patient groups. Conclusion: HMW-adiponectin is more strongly associated with very low density lipoprotein remnant metabolism than glucose utilization in type 1 diabetic patients receiving short-acting insulin analogs.

Original languageEnglish
Pages (from-to)207-216
Number of pages10
JournalJournal of Atherosclerosis and Thrombosis
Volume16
Issue number3
Publication statusPublished - 2009

Fingerprint

Adiponectin
Triglycerides
Molecular Weight
Molecular weight
Bread
Short-Acting Insulin
Butter
Healthy Volunteers
Fasting
Blood
Apolipoprotein B-48
Glucose
VLDL Lipoproteins
Lipoprotein Lipase
Metabolism
Meals
Lipids
Plasmas

Keywords

  • ApoB48
  • Insulin therapy
  • Postprandial
  • RLP-triglyceride

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

Cite this

Maruyama, C., Ishibashi, R., Araki, R., Koike, S., Hirose, H., & Maruyama, T. (2009). HMW-adiponectin associates with triglyceride concentrations in type 1 diabetic patients. Journal of Atherosclerosis and Thrombosis, 16(3), 207-216.

HMW-adiponectin associates with triglyceride concentrations in type 1 diabetic patients. / Maruyama, Chizuko; Ishibashi, Rieko; Araki, Risa; Koike, Shino; Hirose, Hiroshi; Maruyama, Taro.

In: Journal of Atherosclerosis and Thrombosis, Vol. 16, No. 3, 2009, p. 207-216.

Research output: Contribution to journalArticle

Maruyama, C, Ishibashi, R, Araki, R, Koike, S, Hirose, H & Maruyama, T 2009, 'HMW-adiponectin associates with triglyceride concentrations in type 1 diabetic patients', Journal of Atherosclerosis and Thrombosis, vol. 16, no. 3, pp. 207-216.
Maruyama, Chizuko ; Ishibashi, Rieko ; Araki, Risa ; Koike, Shino ; Hirose, Hiroshi ; Maruyama, Taro. / HMW-adiponectin associates with triglyceride concentrations in type 1 diabetic patients. In: Journal of Atherosclerosis and Thrombosis. 2009 ; Vol. 16, No. 3. pp. 207-216.
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AU - Hirose, Hiroshi

AU - Maruyama, Taro

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AB - Aim: The objective of this study was to investigate the relation between serum high molecular weight (HMW)-adiponectin concentration and fasting and postprandial blood glycemic and lipid parameters in type 1 diabetic patients. Methods: Type 1 diabetic patients treated with short-acting insulin analogs and healthy volunteers were recruited. The subjects were divided into two groups based on the mean HMW-adiponectin value of 12.2 mg/L: low HMW-adiponectin (men/women=7/2) and high HMW-adiponectin (men/ women=3/8). Blood samples were collected after an overnight fast, and 30-180 min after consuming white bread (B) or white bread with butter (BB). Results: Type 1 diabetic patients with high HMW-adiponectin had lower triglyceride and remnant like particle (RLP)-triglyceride concentrations than those with low HMW-adiponectin (p<0.01), and had a higher lipoprotein lipase mass (p<0.01) than healthy subjects (men/women=8/ 6). After B and BB meals, type 1 diabetic patients with high HMW-adiponectin consistently had lower triglyceride and RLP-triglyceride concentrations for up to 180 min than those with low HMW-adiponectin (p<0.01); however, apoB48 did not differ between these two groups. Fasting and postprandial plasma glucose were higher in both diabetic groups than in healthy subjects (p<0.001), with no significant difference between patient groups. Conclusion: HMW-adiponectin is more strongly associated with very low density lipoprotein remnant metabolism than glucose utilization in type 1 diabetic patients receiving short-acting insulin analogs.

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