hnRNP-U enhances the expression of specific genes by stabilizing mRNA

Masato Yugami, Yasuaki Kabe, Yuki Yamaguchi, Tadashi Wada, Hiroshi Handa

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are thought to be involved in pre-mRNA processing. hnRNP-U, also termed scaffold attachment factor A (SAF-A), binds to pre-mRNA and nuclear matrix/scaffold attachment region DNA elements. However, its role in the regulation of gene expression is as yet poorly understood. In the present study, we show that hnRNP-U specifically enhances the expression of tumor necrosis factor α mRNA by increasing its stability, possibly through binding to the 3′ untranslated region. We also show that hnRNP-U enhances the expression of several other genes as well, including GADD45A, HEXIM1, HOXA2, IER3, NHLH2, and ZFY, by binding to and stabilizing these mRNAs. These results suggest that hnRNP-U enhances the expression of specific genes by regulating mRNA stability.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalFEBS Letters
Volume581
Issue number1
DOIs
Publication statusPublished - 2007 Jan 9

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Keywords

  • 3′ Untranslated region
  • Gene expression
  • Heterogeneous ribonucleoprotein
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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