Highly enantioselective homogeneous catalysis under continuous-flow conditions was established for the cobalt-catalyzed borohydride reduction of tetralone derivatives. A microreactor allowed higher reaction temperature with the residence time of 12 min than the corresponding batch system to maintain enantioselectivity as well as reactivity. The present system was directly applied to gram-scale synthesis to afford the reduced product with 92% ee.
|Number of pages||6|
|Journal||Organic Process Research and Development|
|Publication status||Published - 2012 Jun 15|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry