Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata

Arihiro Iwasaki, Takato Tadenuma, Shimpe Sumimoto, Ikuma Shiota, Teruhiko Matsubara, Yumiko Saito-Nakano, Tomoyoshi Nozaki, Toshinori Sato, Kiyotake Suenaga

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hoshinoamides A (1) and B (2), new acyclic lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata. Their structures were elucidated by spectroscopic analyses and degradation reactions. Hoshinoamides A (1) and B (2) did not exhibit any cytotoxicity against HeLa cells at 10 μM, but inhibited the in vitro growth of the malarial parasite Plasmodium falciparum (IC50 = 0.52 and 1.0 μM, respectively).

Original languageEnglish
Pages (from-to)2545-2552
Number of pages8
JournalJournal of Natural Products
Volume81
Issue number11
DOIs
Publication statusPublished - 2018 Nov 26

Fingerprint

Lipopeptides
Cyanobacteria
Plasmodium falciparum
Cytotoxicity
HeLa Cells
Inhibitory Concentration 50
Parasites
Degradation
Growth
In Vitro Techniques

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata. / Iwasaki, Arihiro; Tadenuma, Takato; Sumimoto, Shimpe; Shiota, Ikuma; Matsubara, Teruhiko; Saito-Nakano, Yumiko; Nozaki, Tomoyoshi; Sato, Toshinori; Suenaga, Kiyotake.

In: Journal of Natural Products, Vol. 81, No. 11, 26.11.2018, p. 2545-2552.

Research output: Contribution to journalArticle

Iwasaki, Arihiro ; Tadenuma, Takato ; Sumimoto, Shimpe ; Shiota, Ikuma ; Matsubara, Teruhiko ; Saito-Nakano, Yumiko ; Nozaki, Tomoyoshi ; Sato, Toshinori ; Suenaga, Kiyotake. / Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata. In: Journal of Natural Products. 2018 ; Vol. 81, No. 11. pp. 2545-2552.
@article{0057f80d057b498fb9b26e080aff471e,
title = "Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata",
abstract = "Hoshinoamides A (1) and B (2), new acyclic lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata. Their structures were elucidated by spectroscopic analyses and degradation reactions. Hoshinoamides A (1) and B (2) did not exhibit any cytotoxicity against HeLa cells at 10 μM, but inhibited the in vitro growth of the malarial parasite Plasmodium falciparum (IC50 = 0.52 and 1.0 μM, respectively).",
author = "Arihiro Iwasaki and Takato Tadenuma and Shimpe Sumimoto and Ikuma Shiota and Teruhiko Matsubara and Yumiko Saito-Nakano and Tomoyoshi Nozaki and Toshinori Sato and Kiyotake Suenaga",
year = "2018",
month = "11",
day = "26",
doi = "10.1021/acs.jnatprod.8b00643",
language = "English",
volume = "81",
pages = "2545--2552",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "11",

}

TY - JOUR

T1 - Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata

AU - Iwasaki, Arihiro

AU - Tadenuma, Takato

AU - Sumimoto, Shimpe

AU - Shiota, Ikuma

AU - Matsubara, Teruhiko

AU - Saito-Nakano, Yumiko

AU - Nozaki, Tomoyoshi

AU - Sato, Toshinori

AU - Suenaga, Kiyotake

PY - 2018/11/26

Y1 - 2018/11/26

N2 - Hoshinoamides A (1) and B (2), new acyclic lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata. Their structures were elucidated by spectroscopic analyses and degradation reactions. Hoshinoamides A (1) and B (2) did not exhibit any cytotoxicity against HeLa cells at 10 μM, but inhibited the in vitro growth of the malarial parasite Plasmodium falciparum (IC50 = 0.52 and 1.0 μM, respectively).

AB - Hoshinoamides A (1) and B (2), new acyclic lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata. Their structures were elucidated by spectroscopic analyses and degradation reactions. Hoshinoamides A (1) and B (2) did not exhibit any cytotoxicity against HeLa cells at 10 μM, but inhibited the in vitro growth of the malarial parasite Plasmodium falciparum (IC50 = 0.52 and 1.0 μM, respectively).

UR - http://www.scopus.com/inward/record.url?scp=85056429291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056429291&partnerID=8YFLogxK

U2 - 10.1021/acs.jnatprod.8b00643

DO - 10.1021/acs.jnatprod.8b00643

M3 - Article

C2 - 30387355

AN - SCOPUS:85056429291

VL - 81

SP - 2545

EP - 2552

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 11

ER -