Host factors and biomarkers associated with poor outcomes in adults with invasive pneumococcal disease

Shigeo Hanada, Satoshi Iwata, Kazuma Kishi, Miyuki Morozumi, Naoko Chiba, Takeaki Wajima, Misako Takata, Kimiko Ubukata

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10 Citations (Scopus)

Abstract

Background: Invasive pneumococcal disease (IPD) causes considerable morbidity and mortality.We aimed to identify host factors and biomarkers associated with poor outcomes in adult patients with IPD in Japan, which has a rapidly-aging population. Methods: In a large-scale surveillance study of 506 Japanese adults with IPD, we investigated the role of host factors, disease severity, biomarkers based on clinical laboratory data, treatment regimens, and bacterial factors on 28-day mortality. Results: Overall mortality was 24.1%, and the mortality rate increased from 10.0%in patients aged

Original languageEnglish
Article numbere0147877
JournalPLoS One
Volume11
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Hanada, S., Iwata, S., Kishi, K., Morozumi, M., Chiba, N., Wajima, T., Takata, M., & Ubukata, K. (2016). Host factors and biomarkers associated with poor outcomes in adults with invasive pneumococcal disease. PLoS One, 11(1), [e0147877]. https://doi.org/10.1371/journal.pone.0147877