How does the royal family of tudor rule the PIWI-interacting RNA pathway?

Mikiko C. Siomi, Taro Mannen, Haruhiko Siomi

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

PIWI (F-element-induced wimpy testis) proteins are a subset of the Argonaute proteins and are expressed predominantly in the germlines of a variety of organisms, including Drosophila and mammals. FIWI proteins associate specifically with FIWI-interacting RNAs (piRNAs), small RNAs that are also expressed predominantly in germlines, and silence transposable DNA elements and other genes showing complementarities to the sequences of associated piRNAs. This mechanism helps to maintain the integrity of the genome and the development of gametes. PIWI proteins have been shown recently to contain symmetrical dimethyl arginines (sDMAs), and this modification is mediated by the methyltransferase PRMT5 (also known as Dart5 or Capsuleen). It was then demonstrated that multiple members of the Tudor (Tud) family of proteins, which are necessary for gametogenesis in both flies and mice, associate with FIWI proteins specifically through sDMAs in various but particular combinations. Although Tud domains in Tud family members are known to be sDMA-binding modules, involvement of the Tudor family at the molecular level in the piRNA pathway has only recently come into focus.

Original languageEnglish
Pages (from-to)636-646
Number of pages11
JournalGenes and Development
Volume24
Issue number7
DOIs
Publication statusPublished - 2010 Apr 1

Fingerprint

RNA
Arginine
Proteins
Argonaute Proteins
Gametogenesis
DNA Transposable Elements
Methyltransferases
Germ Cells
Diptera
Small Interfering RNA
Drosophila
Testis
Mammals
Genome
Genes

Keywords

  • PiRNA
  • PIWI
  • PRMT5
  • RNA silencing
  • SDMA
  • Tudor

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Medicine(all)

Cite this

How does the royal family of tudor rule the PIWI-interacting RNA pathway? / Siomi, Mikiko C.; Mannen, Taro; Siomi, Haruhiko.

In: Genes and Development, Vol. 24, No. 7, 01.04.2010, p. 636-646.

Research output: Contribution to journalArticle

Siomi, Mikiko C. ; Mannen, Taro ; Siomi, Haruhiko. / How does the royal family of tudor rule the PIWI-interacting RNA pathway?. In: Genes and Development. 2010 ; Vol. 24, No. 7. pp. 636-646.
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