How to Create an Embryo Penetration Route

Hiroshi Uchida, Tetsuo Maruyama, Hirotaka Masuda, Sayaka Uchida, Fumie Miki, Hanako Hihara, Satomi Katakura, Yushi Yoshimasa, Mamoru Tanaka

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Numerous past investigations into human implantation have tended to pay attention to the mechanism of embryo adhesion to endometrial cells or embryo invasion into endometrial stromal tissue. For successful pregnancy, however, embryo penetration through the endometrial epithelial cell (EEC) sheet is also absolutely required. To improve the performance of assisted reproductive technology, implantation studies should also focus on EEC dynamics, in particular, the action of EECs during embryo penetration. Although only EEC apoptosis has been proposed as a mechanism for the formation of the embryo penetration route, we have also recently reported that characteristic EEC collective motion, regulated by the epithelial to mesenchymal transition, also plays a key role in permitting embryo penetration. We review here how EECs form embryo penetration routes in light of our findings.

Original languageEnglish
Pages (from-to)326-332
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Volume75
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1

Fingerprint

Embryonic Structures
Epithelial Cells
European Union
Assisted Reproductive Techniques
Epithelial-Mesenchymal Transition
Apoptosis
Pregnancy

Keywords

  • Apoptosis
  • endometrial epithelial cell
  • epithelial to mesenchymal transition
  • motility
  • steroid hormone

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

How to Create an Embryo Penetration Route. / Uchida, Hiroshi; Maruyama, Tetsuo; Masuda, Hirotaka; Uchida, Sayaka; Miki, Fumie; Hihara, Hanako; Katakura, Satomi; Yoshimasa, Yushi; Tanaka, Mamoru.

In: American Journal of Reproductive Immunology, Vol. 75, No. 3, 01.03.2016, p. 326-332.

Research output: Contribution to journalReview article

Uchida, Hiroshi ; Maruyama, Tetsuo ; Masuda, Hirotaka ; Uchida, Sayaka ; Miki, Fumie ; Hihara, Hanako ; Katakura, Satomi ; Yoshimasa, Yushi ; Tanaka, Mamoru. / How to Create an Embryo Penetration Route. In: American Journal of Reproductive Immunology. 2016 ; Vol. 75, No. 3. pp. 326-332.
@article{8c159c76cbaa46509e3ee1d31b962125,
title = "How to Create an Embryo Penetration Route",
abstract = "Numerous past investigations into human implantation have tended to pay attention to the mechanism of embryo adhesion to endometrial cells or embryo invasion into endometrial stromal tissue. For successful pregnancy, however, embryo penetration through the endometrial epithelial cell (EEC) sheet is also absolutely required. To improve the performance of assisted reproductive technology, implantation studies should also focus on EEC dynamics, in particular, the action of EECs during embryo penetration. Although only EEC apoptosis has been proposed as a mechanism for the formation of the embryo penetration route, we have also recently reported that characteristic EEC collective motion, regulated by the epithelial to mesenchymal transition, also plays a key role in permitting embryo penetration. We review here how EECs form embryo penetration routes in light of our findings.",
keywords = "Apoptosis, endometrial epithelial cell, epithelial to mesenchymal transition, motility, steroid hormone",
author = "Hiroshi Uchida and Tetsuo Maruyama and Hirotaka Masuda and Sayaka Uchida and Fumie Miki and Hanako Hihara and Satomi Katakura and Yushi Yoshimasa and Mamoru Tanaka",
year = "2016",
month = "3",
day = "1",
doi = "10.1111/aji.12476",
language = "English",
volume = "75",
pages = "326--332",
journal = "American Journal of Reproductive Immunology and Microbiology",
issn = "8755-8920",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - How to Create an Embryo Penetration Route

AU - Uchida, Hiroshi

AU - Maruyama, Tetsuo

AU - Masuda, Hirotaka

AU - Uchida, Sayaka

AU - Miki, Fumie

AU - Hihara, Hanako

AU - Katakura, Satomi

AU - Yoshimasa, Yushi

AU - Tanaka, Mamoru

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Numerous past investigations into human implantation have tended to pay attention to the mechanism of embryo adhesion to endometrial cells or embryo invasion into endometrial stromal tissue. For successful pregnancy, however, embryo penetration through the endometrial epithelial cell (EEC) sheet is also absolutely required. To improve the performance of assisted reproductive technology, implantation studies should also focus on EEC dynamics, in particular, the action of EECs during embryo penetration. Although only EEC apoptosis has been proposed as a mechanism for the formation of the embryo penetration route, we have also recently reported that characteristic EEC collective motion, regulated by the epithelial to mesenchymal transition, also plays a key role in permitting embryo penetration. We review here how EECs form embryo penetration routes in light of our findings.

AB - Numerous past investigations into human implantation have tended to pay attention to the mechanism of embryo adhesion to endometrial cells or embryo invasion into endometrial stromal tissue. For successful pregnancy, however, embryo penetration through the endometrial epithelial cell (EEC) sheet is also absolutely required. To improve the performance of assisted reproductive technology, implantation studies should also focus on EEC dynamics, in particular, the action of EECs during embryo penetration. Although only EEC apoptosis has been proposed as a mechanism for the formation of the embryo penetration route, we have also recently reported that characteristic EEC collective motion, regulated by the epithelial to mesenchymal transition, also plays a key role in permitting embryo penetration. We review here how EECs form embryo penetration routes in light of our findings.

KW - Apoptosis

KW - endometrial epithelial cell

KW - epithelial to mesenchymal transition

KW - motility

KW - steroid hormone

UR - http://www.scopus.com/inward/record.url?scp=84977473792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84977473792&partnerID=8YFLogxK

U2 - 10.1111/aji.12476

DO - 10.1111/aji.12476

M3 - Review article

C2 - 26732539

AN - SCOPUS:84977473792

VL - 75

SP - 326

EP - 332

JO - American Journal of Reproductive Immunology and Microbiology

JF - American Journal of Reproductive Immunology and Microbiology

SN - 8755-8920

IS - 3

ER -