Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

Rimpei Morita, Nathalie Schmitt, Salah Eddine Bentebibel, Rajaram Ranganathan, Laure Bourdery, Gerard Zurawski, Emile Foucat, Melissa Dullaers, SangKon Oh, Natalie Sabzghabaei, Elizabeth M. Lavecchio, Marilynn Punaro, Virginia Pascual, Jacques Banchereau, Hideki Ueno

Research output: Contribution to journalArticle

430 Citations (Scopus)

Abstract

Although a fraction of human blood memory CD4+ T cells expresses chemokine (C-X-C motif) receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well established. Here we show that human blood CXCR5+CD4+ T cells share functional properties with Tfh cells and appear to represent their circulating memory compartment. Blood CXCR5+CD4+ T cells comprised three subsets: T helper 1 (Th1), Th2, and Th17 cells. Th2 and Th17 cells within CXCR5+, but not within CXCR5-, compartment efficiently induced naive B cells to produce immunoglobulins via interleukin-21 (IL-21). In contrast, Th1 cells from both CXCR5+ and CXCR5- compartments lacked the capacity to help B cells. Patients with juvenile dermatomyositis, a systemic autoimmune disease, displayed a profound skewing of blood CXCR5+ Th cell subsets toward Th2 and Th17 cells. Importantly, the skewing of subsets correlated with disease activity and frequency of blood plasmablasts. Collectively, our study suggests that an altered balance of Tfh cell subsets contributes to human autoimmunity.

Original languageEnglish
Pages (from-to)108-121
Number of pages14
JournalImmunity
Volume34
Issue number1
DOIs
Publication statusPublished - 2011 Jan 28
Externally publishedYes

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CD4 Antigens
Th17 Cells
Th2 Cells
T-Lymphocytes
Helper-Inducer T-Lymphocytes
Antibodies
Th1 Cells
B-Lymphocytes
CCR Receptors
Autoimmunity
Autoimmune Diseases
Immunoglobulins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion. / Morita, Rimpei; Schmitt, Nathalie; Bentebibel, Salah Eddine; Ranganathan, Rajaram; Bourdery, Laure; Zurawski, Gerard; Foucat, Emile; Dullaers, Melissa; Oh, SangKon; Sabzghabaei, Natalie; Lavecchio, Elizabeth M.; Punaro, Marilynn; Pascual, Virginia; Banchereau, Jacques; Ueno, Hideki.

In: Immunity, Vol. 34, No. 1, 28.01.2011, p. 108-121.

Research output: Contribution to journalArticle

Morita, R, Schmitt, N, Bentebibel, SE, Ranganathan, R, Bourdery, L, Zurawski, G, Foucat, E, Dullaers, M, Oh, S, Sabzghabaei, N, Lavecchio, EM, Punaro, M, Pascual, V, Banchereau, J & Ueno, H 2011, 'Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion', Immunity, vol. 34, no. 1, pp. 108-121. https://doi.org/10.1016/j.immuni.2010.12.012
Morita, Rimpei ; Schmitt, Nathalie ; Bentebibel, Salah Eddine ; Ranganathan, Rajaram ; Bourdery, Laure ; Zurawski, Gerard ; Foucat, Emile ; Dullaers, Melissa ; Oh, SangKon ; Sabzghabaei, Natalie ; Lavecchio, Elizabeth M. ; Punaro, Marilynn ; Pascual, Virginia ; Banchereau, Jacques ; Ueno, Hideki. / Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion. In: Immunity. 2011 ; Vol. 34, No. 1. pp. 108-121.
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