Human brain glucose metabolism mapping using multislice 2D 1H-13C correlation HSQC spectroscopy

Hidehiro Watanabe, M. Umeda, Y. Ishihara, K. Okamoto, Koichi Oshio, T. Kanamatsu, Y. Tsukada

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A method for multivolume 2D 1H-13C correlation spectroscopy, multislice heteronuclear single quantum coherence (HSQC), is proposed. This permits human brain metabolism from glucose to amino acids to be followed using a 2-T whole-body scanner. The modifications from the conventional HSQC are that the 180°(13C) and 180°(1H) pulses are separated in time in the preparation period and that the 180°(13C) pulse is applied at 1/(4J(CH)) before the 90°(1H) polarization transfer (PT) pulse. The preparation (echo) time can be set longer than 1/(2J(CH)) so that, even in a whole-body system, slice-selective pulses and gradients can be applied. Another modification is that the 90°(1H) reverse PT pulses after the creation of 21(z)S(z) are used as multislice pulses. The time-course of glutamate C4 could be followed with 15-min temporal resolution from the HSQC spectra obtained from the brains of volunteers after the oral administration of glucose C1, and the maximum S/N was 3. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)525-533
Number of pages9
JournalMagnetic Resonance in Medicine
Volume43
Issue number4
DOIs
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Spectrum Analysis
Glucose
Brain
Oral Administration
Glutamic Acid
Volunteers
Amino Acids

Keywords

  • C-MRS
  • H-detection
  • In vivo
  • Mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Human brain glucose metabolism mapping using multislice 2D 1H-13C correlation HSQC spectroscopy. / Watanabe, Hidehiro; Umeda, M.; Ishihara, Y.; Okamoto, K.; Oshio, Koichi; Kanamatsu, T.; Tsukada, Y.

In: Magnetic Resonance in Medicine, Vol. 43, No. 4, 2000, p. 525-533.

Research output: Contribution to journalArticle

Watanabe, Hidehiro ; Umeda, M. ; Ishihara, Y. ; Okamoto, K. ; Oshio, Koichi ; Kanamatsu, T. ; Tsukada, Y. / Human brain glucose metabolism mapping using multislice 2D 1H-13C correlation HSQC spectroscopy. In: Magnetic Resonance in Medicine. 2000 ; Vol. 43, No. 4. pp. 525-533.
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