Abstract
A method for multivolume 2D 1H-13C correlation spectroscopy, multislice heteronuclear single quantum coherence (HSQC), is proposed. This permits human brain metabolism from glucose to amino acids to be followed using a 2-T whole-body scanner. The modifications from the conventional HSQC are that the 180°(13C) and 180°(1H) pulses are separated in time in the preparation period and that the 180°(13C) pulse is applied at 1/(4J(CH)) before the 90°(1H) polarization transfer (PT) pulse. The preparation (echo) time can be set longer than 1/(2J(CH)) so that, even in a whole-body system, slice-selective pulses and gradients can be applied. Another modification is that the 90°(1H) reverse PT pulses after the creation of 21(z)S(z) are used as multislice pulses. The time-course of glutamate C4 could be followed with 15-min temporal resolution from the HSQC spectra obtained from the brains of volunteers after the oral administration of glucose C1, and the maximum S/N was 3. (C) 2000 Wiley-Liss, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 525-533 |
| Number of pages | 9 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 43 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2000 |
| Externally published | Yes |
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Keywords
- C-MRS
- H-detection
- In vivo
- Mapping
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Human brain glucose metabolism mapping using multislice 2D 1H-13C correlation HSQC spectroscopy. / Watanabe, Hidehiro; Umeda, M.; Ishihara, Y.; Okamoto, K.; Oshio, Koichi; Kanamatsu, T.; Tsukada, Y.
In: Magnetic Resonance in Medicine, Vol. 43, No. 4, 2000, p. 525-533.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human brain glucose metabolism mapping using multislice 2D 1H-13C correlation HSQC spectroscopy
AU - Watanabe, Hidehiro
AU - Umeda, M.
AU - Ishihara, Y.
AU - Okamoto, K.
AU - Oshio, Koichi
AU - Kanamatsu, T.
AU - Tsukada, Y.
PY - 2000
Y1 - 2000
N2 - A method for multivolume 2D 1H-13C correlation spectroscopy, multislice heteronuclear single quantum coherence (HSQC), is proposed. This permits human brain metabolism from glucose to amino acids to be followed using a 2-T whole-body scanner. The modifications from the conventional HSQC are that the 180°(13C) and 180°(1H) pulses are separated in time in the preparation period and that the 180°(13C) pulse is applied at 1/(4J(CH)) before the 90°(1H) polarization transfer (PT) pulse. The preparation (echo) time can be set longer than 1/(2J(CH)) so that, even in a whole-body system, slice-selective pulses and gradients can be applied. Another modification is that the 90°(1H) reverse PT pulses after the creation of 21(z)S(z) are used as multislice pulses. The time-course of glutamate C4 could be followed with 15-min temporal resolution from the HSQC spectra obtained from the brains of volunteers after the oral administration of glucose C1, and the maximum S/N was 3. (C) 2000 Wiley-Liss, Inc.
AB - A method for multivolume 2D 1H-13C correlation spectroscopy, multislice heteronuclear single quantum coherence (HSQC), is proposed. This permits human brain metabolism from glucose to amino acids to be followed using a 2-T whole-body scanner. The modifications from the conventional HSQC are that the 180°(13C) and 180°(1H) pulses are separated in time in the preparation period and that the 180°(13C) pulse is applied at 1/(4J(CH)) before the 90°(1H) polarization transfer (PT) pulse. The preparation (echo) time can be set longer than 1/(2J(CH)) so that, even in a whole-body system, slice-selective pulses and gradients can be applied. Another modification is that the 90°(1H) reverse PT pulses after the creation of 21(z)S(z) are used as multislice pulses. The time-course of glutamate C4 could be followed with 15-min temporal resolution from the HSQC spectra obtained from the brains of volunteers after the oral administration of glucose C1, and the maximum S/N was 3. (C) 2000 Wiley-Liss, Inc.
KW - C-MRS
KW - H-detection
KW - In vivo
KW - Mapping
UR - http://www.scopus.com/inward/record.url?scp=0034066220&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034066220&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1522-2594(200004)43:4<525::AID-MRM6>3.0.CO;2-K
DO - 10.1002/(SICI)1522-2594(200004)43:4<525::AID-MRM6>3.0.CO;2-K
M3 - Article
VL - 43
SP - 525
EP - 533
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 4
ER -