Human Chorionic Gonadotropin Stimulation Test in Prepubertal Children with Micropenis Can Accurately Predict Leydig Cell Function in Pubertal or Postpubertal Adolescents

Tomohiro Ishii, Nobutake Matsuo, Seiji Sato, Tsutomu Ogata, Shinya Tamai, Makoto Anzo, Tsutomu Kamimaki, Goro Sasaki, Mikako Inokuchi, Naoaki Hori, Naoko Amano, Satoshi Narumi, Hironori Shibata, Tomonobu Hasegawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

To evaluate the accuracy of the human chorionic gonadotropin (hCG) stimulation test in children with micropenis in predicting later Leydig cell function. Methods: We conducted a retrospective investigation of testosterone response to a 3-day hCG test (3,000 IU/m2/day) in prepuberty to indicate the need for hormone replacement therapy (HRT) in adolescence. Results: Fifty Japanese boys (range, 0.8-15.4 years of age; median, 8.9) with micropenis were enrolled. Thirty-four spontaneously developed puberty and preserved the ability of testosterone production (group 1), while 16 did not develop any pubertal signs without HRT (group 2). Serum testosterone levels after the hCG test (post-hCG T) in group 2 (range,

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalHormone Research in Paediatrics
Volume84
Issue number5
DOIs
Publication statusPublished - 2015 Nov 1

Keywords

  • Human chorionic gonadotropin stimulation test
  • Hypogonadism
  • Leydig cell
  • Micropenis
  • Receiver-operating characteristics analysis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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