Human herpes virus-8-associated multicentric Castleman’s disease in an HIV-positive patient presenting with relapsing and remitting hyponatraemia

Hiroaki Sasaki, Takuya Maeda, Yu Hara, Morichika Osa, Kazuo Imai, Kota Moriguchi, Kei Mikita, Yuji Fujikura, Kenichi Kaida, Akihiko Kawana

Research output: Contribution to journalArticle

Abstract

We report a case of human herpes virus-8-associated multicentric Castleman’s disease in an HIV-positive patient with hyponatraemia. A 65-year-old man was admitted with relapsing and remitting fever, scattered skin eruptions and hepatosplenomegaly following combination antiretroviral therapy for his HIV infection. Based on histopathological findings, he was diagnosed as having human herpes virus-8-associated multicentric Castleman’s disease and was treated with four-weekly infusions of rituximab. Prior to receiving chemotherapy, we observed several suspected biomarkers of disease activity, positive correlations between plasma human herpes virus-8 viral load and the levels of plasma interleukin-6, C-reactive protein and soluble interleukin-2 receptor, and negative correlations between platelet count, albumin levels and especially serum sodium levels. We hypothesize that non-osmotic release of plasma antidiuretic hormone is a cause of hyponatraemia in human herpes virus-8-associated multicentric Castleman’s disease and that relapsing and remitting hyponatraemia could be correlated with plasma human herpes virus-8 viral load.

Original languageEnglish
Pages (from-to)909-911
Number of pages3
JournalInternational Journal of STD and AIDS
Volume26
Issue number12
DOIs
Publication statusPublished - 2015 Oct 1
Externally publishedYes

Keywords

  • AIDS
  • antidiuretic hormone
  • central pontine myelinolysis
  • HIV
  • human herpes virus-8
  • hyponatraemia
  • interleukin-6
  • Multicentric Castleman disease
  • sodium

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases
  • Medicine(all)

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