Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia

Mamoru Tochigi, Jun Ohashi, Tadashi Umekage, Kazuhisa Kohda, Hiroyuki Hibino, Takeshi Otowa, Tetsuya Marui, Kanji Masui, Yuriko Sugahara, Ryo Kanamori, Takeo Juji, Nobumasa Kato, Katsushi Tokunaga, Tsukasa Sasaki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Several studies, including one from Japan, have observed an increase of Human Leukocyte Antigen (HLA)-A24 and A26 in schizophrenia, although others failed to observe the increase. No use of systematic diagnostic criteria and a not-adequately reliable typing technique might have affected the results in the previous studies. We investigated HLA-A specificities in Japanese patients with schizophrenia (DSM-IV), recruited from the same area as in the early Japanese study. A DNA-based technique (polymerase chain reaction-microtiter plate hybridization) was employed. No significant difference was observed in frequencies of any HLA-A specificities between patients and controls, including A24 and A26. No significant association was found between the HLA-A and birth-season in patients. Thus, no evidence was obtained for an association between HLA-A and schizophrenia from the Japanese population.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalNeuroscience Letters
Volume329
Issue number2
DOIs
Publication statusPublished - 2002 Aug 30
Externally publishedYes

Fingerprint

HLA Antigens
Schizophrenia
Parturition
faropenem medoxomil
Diagnostic and Statistical Manual of Mental Disorders
Japan
Polymerase Chain Reaction
DNA
Population

Keywords

  • A24
  • A26
  • Human leukocyte antigen
  • Japanese
  • Schizophrenia
  • Season of birth

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia. / Tochigi, Mamoru; Ohashi, Jun; Umekage, Tadashi; Kohda, Kazuhisa; Hibino, Hiroyuki; Otowa, Takeshi; Marui, Tetsuya; Masui, Kanji; Sugahara, Yuriko; Kanamori, Ryo; Juji, Takeo; Kato, Nobumasa; Tokunaga, Katsushi; Sasaki, Tsukasa.

In: Neuroscience Letters, Vol. 329, No. 2, 30.08.2002, p. 201-204.

Research output: Contribution to journalArticle

Tochigi, M, Ohashi, J, Umekage, T, Kohda, K, Hibino, H, Otowa, T, Marui, T, Masui, K, Sugahara, Y, Kanamori, R, Juji, T, Kato, N, Tokunaga, K & Sasaki, T 2002, 'Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia', Neuroscience Letters, vol. 329, no. 2, pp. 201-204. https://doi.org/10.1016/S0304-3940(02)00653-5
Tochigi, Mamoru ; Ohashi, Jun ; Umekage, Tadashi ; Kohda, Kazuhisa ; Hibino, Hiroyuki ; Otowa, Takeshi ; Marui, Tetsuya ; Masui, Kanji ; Sugahara, Yuriko ; Kanamori, Ryo ; Juji, Takeo ; Kato, Nobumasa ; Tokunaga, Katsushi ; Sasaki, Tsukasa. / Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia. In: Neuroscience Letters. 2002 ; Vol. 329, No. 2. pp. 201-204.
@article{968374dcebb840a6975aad2b13c5d248,
title = "Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia",
abstract = "Several studies, including one from Japan, have observed an increase of Human Leukocyte Antigen (HLA)-A24 and A26 in schizophrenia, although others failed to observe the increase. No use of systematic diagnostic criteria and a not-adequately reliable typing technique might have affected the results in the previous studies. We investigated HLA-A specificities in Japanese patients with schizophrenia (DSM-IV), recruited from the same area as in the early Japanese study. A DNA-based technique (polymerase chain reaction-microtiter plate hybridization) was employed. No significant difference was observed in frequencies of any HLA-A specificities between patients and controls, including A24 and A26. No significant association was found between the HLA-A and birth-season in patients. Thus, no evidence was obtained for an association between HLA-A and schizophrenia from the Japanese population.",
keywords = "A24, A26, Human leukocyte antigen, Japanese, Schizophrenia, Season of birth",
author = "Mamoru Tochigi and Jun Ohashi and Tadashi Umekage and Kazuhisa Kohda and Hiroyuki Hibino and Takeshi Otowa and Tetsuya Marui and Kanji Masui and Yuriko Sugahara and Ryo Kanamori and Takeo Juji and Nobumasa Kato and Katsushi Tokunaga and Tsukasa Sasaki",
year = "2002",
month = "8",
day = "30",
doi = "10.1016/S0304-3940(02)00653-5",
language = "English",
volume = "329",
pages = "201--204",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia

AU - Tochigi, Mamoru

AU - Ohashi, Jun

AU - Umekage, Tadashi

AU - Kohda, Kazuhisa

AU - Hibino, Hiroyuki

AU - Otowa, Takeshi

AU - Marui, Tetsuya

AU - Masui, Kanji

AU - Sugahara, Yuriko

AU - Kanamori, Ryo

AU - Juji, Takeo

AU - Kato, Nobumasa

AU - Tokunaga, Katsushi

AU - Sasaki, Tsukasa

PY - 2002/8/30

Y1 - 2002/8/30

N2 - Several studies, including one from Japan, have observed an increase of Human Leukocyte Antigen (HLA)-A24 and A26 in schizophrenia, although others failed to observe the increase. No use of systematic diagnostic criteria and a not-adequately reliable typing technique might have affected the results in the previous studies. We investigated HLA-A specificities in Japanese patients with schizophrenia (DSM-IV), recruited from the same area as in the early Japanese study. A DNA-based technique (polymerase chain reaction-microtiter plate hybridization) was employed. No significant difference was observed in frequencies of any HLA-A specificities between patients and controls, including A24 and A26. No significant association was found between the HLA-A and birth-season in patients. Thus, no evidence was obtained for an association between HLA-A and schizophrenia from the Japanese population.

AB - Several studies, including one from Japan, have observed an increase of Human Leukocyte Antigen (HLA)-A24 and A26 in schizophrenia, although others failed to observe the increase. No use of systematic diagnostic criteria and a not-adequately reliable typing technique might have affected the results in the previous studies. We investigated HLA-A specificities in Japanese patients with schizophrenia (DSM-IV), recruited from the same area as in the early Japanese study. A DNA-based technique (polymerase chain reaction-microtiter plate hybridization) was employed. No significant difference was observed in frequencies of any HLA-A specificities between patients and controls, including A24 and A26. No significant association was found between the HLA-A and birth-season in patients. Thus, no evidence was obtained for an association between HLA-A and schizophrenia from the Japanese population.

KW - A24

KW - A26

KW - Human leukocyte antigen

KW - Japanese

KW - Schizophrenia

KW - Season of birth

UR - http://www.scopus.com/inward/record.url?scp=0037199668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037199668&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(02)00653-5

DO - 10.1016/S0304-3940(02)00653-5

M3 - Article

C2 - 12165412

AN - SCOPUS:0037199668

VL - 329

SP - 201

EP - 204

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -