Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia

Mamoru Tochigi, Jun Ohashi, Tadashi Umekage, Kazuhisa Kohda, Hiroyuki Hibino, Takeshi Otowa, Tetsuya Marui, Kanji Masui, Yuriko Sugahara, Ryo Kanamori, Takeo Juji, Nobumasa Kato, Katsushi Tokunaga, Tsukasa Sasaki

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Several studies, including one from Japan, have observed an increase of Human Leukocyte Antigen (HLA)-A24 and A26 in schizophrenia, although others failed to observe the increase. No use of systematic diagnostic criteria and a not-adequately reliable typing technique might have affected the results in the previous studies. We investigated HLA-A specificities in Japanese patients with schizophrenia (DSM-IV), recruited from the same area as in the early Japanese study. A DNA-based technique (polymerase chain reaction-microtiter plate hybridization) was employed. No significant difference was observed in frequencies of any HLA-A specificities between patients and controls, including A24 and A26. No significant association was found between the HLA-A and birth-season in patients. Thus, no evidence was obtained for an association between HLA-A and schizophrenia from the Japanese population.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalNeuroscience Letters
Volume329
Issue number2
DOIs
Publication statusPublished - 2002 Aug 30

Keywords

  • A24
  • A26
  • Human leukocyte antigen
  • Japanese
  • Schizophrenia
  • Season of birth

ASJC Scopus subject areas

  • Neuroscience(all)

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