TY - JOUR
T1 - Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury
AU - Nori, Satoshi
AU - Khazaei, Mohamad
AU - Ahuja, Christopher S.
AU - Yokota, Kazuya
AU - Ahlfors, Jan Eric
AU - Liu, Yang
AU - Wang, Jian
AU - Shibata, Shinsuke
AU - Chio, Jonathon
AU - Hettiaratchi, Marian H.
AU - Führmann, Tobias
AU - Shoichet, Molly S.
AU - Fehlings, Michael G.
N1 - Funding Information:
We thank Dr. Tim Worden for copyediting the manuscript. We thank Mr. Peter Poon for helpful advice about intrathecal injection. We also thank Dr. Malgosia M. Pakulska for the XMC preparation. This study was supported by an Industry Sponsored Collaborative Research Grant with New World Laboratories Inc . and the Canadian Institutes of Health Research (CIHR to M.S.S. and M.G.F.). M.G.F. is supported by the Halbert Chair in Neural Repair and Regeneration and the DeZwirek Foundation . M.S.S. is supported by a Tier 1 Canada Research Chair . Additional grant support is from the Krembil Foundation (to M.G.F. and M.S.S.). S.N. is supported by Japan Society for the Promotion of Science Overseas Research Fellowships.
Funding Information:
We thank Dr. Tim Worden for copyediting the manuscript. We thank Mr. Peter Poon for helpful advice about intrathecal injection. We also thank Dr. Malgosia M. Pakulska for the XMC preparation. This study was supported by an Industry Sponsored Collaborative Research Grant with New World Laboratories Inc. and the Canadian Institutes of Health Research (CIHR to M.S.S. and M.G.F.). M.G.F. is supported by the Halbert Chair in Neural Repair and Regeneration and the DeZwirek Foundation. M.S.S. is supported by a Tier 1 Canada Research Chair. Additional grant support is from the Krembil Foundation (to M.G.F. and M.S.S.). S.N. is supported by Japan Society for the Promotion of Science Overseas Research Fellowships.
Publisher Copyright:
© 2018 The Author(s)
PY - 2018/12/11
Y1 - 2018/12/11
N2 - Fehlings and colleagues investigated the use of directly reprogrammed human neural progenitor cells biased toward an oligodendrogenic fate (oNPCs) combined with sustained delivery of chondroitinase ABC to treat chronic spinal cord injury in an immunodeficient rat model. This combinatorial therapy increased long-term survival of oNPCs, facilitated greater oligodendrocyte differentiation, remyelination of the spared axons by engrafted oNPCs, and neurobehavioral recovery.
AB - Fehlings and colleagues investigated the use of directly reprogrammed human neural progenitor cells biased toward an oligodendrogenic fate (oNPCs) combined with sustained delivery of chondroitinase ABC to treat chronic spinal cord injury in an immunodeficient rat model. This combinatorial therapy increased long-term survival of oNPCs, facilitated greater oligodendrocyte differentiation, remyelination of the spared axons by engrafted oNPCs, and neurobehavioral recovery.
KW - ChABC
KW - cell transplantation
KW - chronic spinal cord injury
KW - combinatorial therapy
KW - crosslinked methylcellulose hydrogel
KW - glial scar
KW - neural progenitor cells
KW - oligodendrocyte
KW - regenerative medicine
KW - remyelination
UR - http://www.scopus.com/inward/record.url?scp=85058598858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058598858&partnerID=8YFLogxK
U2 - 10.1016/j.stemcr.2018.10.017
DO - 10.1016/j.stemcr.2018.10.017
M3 - Article
C2 - 30472009
AN - SCOPUS:85058598858
VL - 11
SP - 1433
EP - 1448
JO - Stem Cell Reports
JF - Stem Cell Reports
SN - 2213-6711
IS - 6
ER -