Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury

Satoshi Nori; Mohamad Khazaei; Christopher S. Ahuja; Kazuya Yokota; Jan Eric Ahlfors; Yang Liu; Jian Wang; Shinsuke Shibata; Jonathon Chio; Marian H. Hettiaratchi; Tobias Führmann; Molly S. Shoichet; Michael G. Fehlings

doi:10.1016/j.stemcr.2018.10.017

Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury

Satoshi Nori, Mohamad Khazaei, Christopher S. Ahuja, Kazuya Yokota, Jan Eric Ahlfors, Yang Liu, Jian Wang, Shinsuke Shibata, Jonathon Chio, Marian H. Hettiaratchi, Tobias Führmann, Molly S. Shoichet, Michael G. Fehlings

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Fehlings and colleagues investigated the use of directly reprogrammed human neural progenitor cells biased toward an oligodendrogenic fate (oNPCs) combined with sustained delivery of chondroitinase ABC to treat chronic spinal cord injury in an immunodeficient rat model. This combinatorial therapy increased long-term survival of oNPCs, facilitated greater oligodendrocyte differentiation, remyelination of the spared axons by engrafted oNPCs, and neurobehavioral recovery.

Original language	English
Pages (from-to)	1433-1448
Number of pages	16
Journal	Stem cell reports
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/j.stemcr.2018.10.017
Publication status	Published - 2018 Dec 11

Keywords

ChABC
cell transplantation
chronic spinal cord injury
combinatorial therapy
crosslinked methylcellulose hydrogel
glial scar
neural progenitor cells
oligodendrocyte
regenerative medicine
remyelination

ASJC Scopus subject areas

Biochemistry
Genetics
Developmental Biology
Cell Biology

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Nori, S., Khazaei, M., Ahuja, C. S., Yokota, K., Ahlfors, J. E., Liu, Y., Wang, J., Shibata, S., Chio, J., Hettiaratchi, M. H., Führmann, T., Shoichet, M. S., & Fehlings, M. G. (2018). Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury. Stem cell reports, 11(6), 1433-1448. https://doi.org/10.1016/j.stemcr.2018.10.017

Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury. / Nori, Satoshi; Khazaei, Mohamad; Ahuja, Christopher S.; Yokota, Kazuya; Ahlfors, Jan Eric; Liu, Yang; Wang, Jian; Shibata, Shinsuke; Chio, Jonathon; Hettiaratchi, Marian H.; Führmann, Tobias; Shoichet, Molly S.; Fehlings, Michael G.

In: Stem cell reports, Vol. 11, No. 6, 11.12.2018, p. 1433-1448.

Research output: Contribution to journal › Article › peer-review

Nori, S, Khazaei, M, Ahuja, CS, Yokota, K, Ahlfors, JE, Liu, Y, Wang, J, Shibata, S, Chio, J, Hettiaratchi, MH, Führmann, T, Shoichet, MS & Fehlings, MG 2018, 'Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury', Stem cell reports, vol. 11, no. 6, pp. 1433-1448. https://doi.org/10.1016/j.stemcr.2018.10.017

Nori, Satoshi ; Khazaei, Mohamad ; Ahuja, Christopher S. ; Yokota, Kazuya ; Ahlfors, Jan Eric ; Liu, Yang ; Wang, Jian ; Shibata, Shinsuke ; Chio, Jonathon ; Hettiaratchi, Marian H. ; Führmann, Tobias ; Shoichet, Molly S. ; Fehlings, Michael G. / Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury. In: Stem cell reports. 2018 ; Vol. 11, No. 6. pp. 1433-1448.

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title = "Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury",

abstract = "Fehlings and colleagues investigated the use of directly reprogrammed human neural progenitor cells biased toward an oligodendrogenic fate (oNPCs) combined with sustained delivery of chondroitinase ABC to treat chronic spinal cord injury in an immunodeficient rat model. This combinatorial therapy increased long-term survival of oNPCs, facilitated greater oligodendrocyte differentiation, remyelination of the spared axons by engrafted oNPCs, and neurobehavioral recovery.",

keywords = "ChABC, cell transplantation, chronic spinal cord injury, combinatorial therapy, crosslinked methylcellulose hydrogel, glial scar, neural progenitor cells, oligodendrocyte, regenerative medicine, remyelination",

author = "Satoshi Nori and Mohamad Khazaei and Ahuja, {Christopher S.} and Kazuya Yokota and Ahlfors, {Jan Eric} and Yang Liu and Jian Wang and Shinsuke Shibata and Jonathon Chio and Hettiaratchi, {Marian H.} and Tobias F{\"u}hrmann and Shoichet, {Molly S.} and Fehlings, {Michael G.}",

note = "Funding Information: We thank Dr. Tim Worden for copyediting the manuscript. We thank Mr. Peter Poon for helpful advice about intrathecal injection. We also thank Dr. Malgosia M. Pakulska for the XMC preparation. This study was supported by an Industry Sponsored Collaborative Research Grant with New World Laboratories Inc . and the Canadian Institutes of Health Research (CIHR to M.S.S. and M.G.F.). M.G.F. is supported by the Halbert Chair in Neural Repair and Regeneration and the DeZwirek Foundation . M.S.S. is supported by a Tier 1 Canada Research Chair . Additional grant support is from the Krembil Foundation (to M.G.F. and M.S.S.). S.N. is supported by Japan Society for the Promotion of Science Overseas Research Fellowships. ",

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