Abstract
Fehlings and colleagues investigated the use of directly reprogrammed human neural progenitor cells biased toward an oligodendrogenic fate (oNPCs) combined with sustained delivery of chondroitinase ABC to treat chronic spinal cord injury in an immunodeficient rat model. This combinatorial therapy increased long-term survival of oNPCs, facilitated greater oligodendrocyte differentiation, remyelination of the spared axons by engrafted oNPCs, and neurobehavioral recovery.
| Original language | English |
|---|---|
| Pages (from-to) | 1433-1448 |
| Number of pages | 16 |
| Journal | Stem Cell Reports |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2018 Dec 11 |
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Keywords
- cell transplantation
- ChABC
- chronic spinal cord injury
- combinatorial therapy
- crosslinked methylcellulose hydrogel
- glial scar
- neural progenitor cells
- oligodendrocyte
- regenerative medicine
- remyelination
ASJC Scopus subject areas
- Biochemistry
- Genetics
- Developmental Biology
- Cell Biology
Cite this
Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury. / Nori, Satoshi; Khazaei, Mohamad; Ahuja, Christopher S.; Yokota, Kazuya; Ahlfors, Jan Eric; Liu, Yang; Wang, Jian; Shibata, Shinsuke; Chio, Jonathon; Hettiaratchi, Marian H.; Führmann, Tobias; Shoichet, Molly S.; Fehlings, Michael G.
In: Stem Cell Reports, Vol. 11, No. 6, 11.12.2018, p. 1433-1448.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury
AU - Nori, Satoshi
AU - Khazaei, Mohamad
AU - Ahuja, Christopher S.
AU - Yokota, Kazuya
AU - Ahlfors, Jan Eric
AU - Liu, Yang
AU - Wang, Jian
AU - Shibata, Shinsuke
AU - Chio, Jonathon
AU - Hettiaratchi, Marian H.
AU - Führmann, Tobias
AU - Shoichet, Molly S.
AU - Fehlings, Michael G.
PY - 2018/12/11
Y1 - 2018/12/11
N2 - Fehlings and colleagues investigated the use of directly reprogrammed human neural progenitor cells biased toward an oligodendrogenic fate (oNPCs) combined with sustained delivery of chondroitinase ABC to treat chronic spinal cord injury in an immunodeficient rat model. This combinatorial therapy increased long-term survival of oNPCs, facilitated greater oligodendrocyte differentiation, remyelination of the spared axons by engrafted oNPCs, and neurobehavioral recovery.
AB - Fehlings and colleagues investigated the use of directly reprogrammed human neural progenitor cells biased toward an oligodendrogenic fate (oNPCs) combined with sustained delivery of chondroitinase ABC to treat chronic spinal cord injury in an immunodeficient rat model. This combinatorial therapy increased long-term survival of oNPCs, facilitated greater oligodendrocyte differentiation, remyelination of the spared axons by engrafted oNPCs, and neurobehavioral recovery.
KW - cell transplantation
KW - ChABC
KW - chronic spinal cord injury
KW - combinatorial therapy
KW - crosslinked methylcellulose hydrogel
KW - glial scar
KW - neural progenitor cells
KW - oligodendrocyte
KW - regenerative medicine
KW - remyelination
UR - http://www.scopus.com/inward/record.url?scp=85058598858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058598858&partnerID=8YFLogxK
U2 - 10.1016/j.stemcr.2018.10.017
DO - 10.1016/j.stemcr.2018.10.017
M3 - Article
C2 - 30472009
AN - SCOPUS:85058598858
VL - 11
SP - 1433
EP - 1448
JO - Stem Cell Reports
JF - Stem Cell Reports
SN - 2213-6711
IS - 6
ER -