Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury

Satoshi Nori, Mohamad Khazaei, Christopher S. Ahuja, Kazuya Yokota, Jan Eric Ahlfors, Yang Liu, Jian Wang, Shinsuke Shibata, Jonathon Chio, Marian H. Hettiaratchi, Tobias Führmann, Molly S. Shoichet, Michael G. Fehlings

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Fehlings and colleagues investigated the use of directly reprogrammed human neural progenitor cells biased toward an oligodendrogenic fate (oNPCs) combined with sustained delivery of chondroitinase ABC to treat chronic spinal cord injury in an immunodeficient rat model. This combinatorial therapy increased long-term survival of oNPCs, facilitated greater oligodendrocyte differentiation, remyelination of the spared axons by engrafted oNPCs, and neurobehavioral recovery.

Original languageEnglish
Pages (from-to)1433-1448
Number of pages16
JournalStem Cell Reports
Volume11
Issue number6
DOIs
Publication statusPublished - 2018 Dec 11

Keywords

  • cell transplantation
  • ChABC
  • chronic spinal cord injury
  • combinatorial therapy
  • crosslinked methylcellulose hydrogel
  • glial scar
  • neural progenitor cells
  • oligodendrocyte
  • regenerative medicine
  • remyelination

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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  • Cite this

    Nori, S., Khazaei, M., Ahuja, C. S., Yokota, K., Ahlfors, J. E., Liu, Y., Wang, J., Shibata, S., Chio, J., Hettiaratchi, M. H., Führmann, T., Shoichet, M. S., & Fehlings, M. G. (2018). Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury. Stem Cell Reports, 11(6), 1433-1448. https://doi.org/10.1016/j.stemcr.2018.10.017