Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury

Satoshi Nori; Mohamad Khazaei; Christopher S. Ahuja; Kazuya Yokota; Jan Eric Ahlfors; Yang Liu; Jian Wang; Shinsuke Shibata; Jonathon Chio; Marian H. Hettiaratchi; Tobias Führmann; Molly S. Shoichet; Michael G. Fehlings

doi:10.1016/j.stemcr.2018.10.017

Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury

Satoshi Nori, Mohamad Khazaei, Christopher S. Ahuja, Kazuya Yokota, Jan Eric Ahlfors, Yang Liu, Jian Wang, Shinsuke Shibata, Jonathon Chio, Marian H. Hettiaratchi, Tobias Führmann, Molly S. Shoichet, Michael G. Fehlings

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

Fehlings and colleagues investigated the use of directly reprogrammed human neural progenitor cells biased toward an oligodendrogenic fate (oNPCs) combined with sustained delivery of chondroitinase ABC to treat chronic spinal cord injury in an immunodeficient rat model. This combinatorial therapy increased long-term survival of oNPCs, facilitated greater oligodendrocyte differentiation, remyelination of the spared axons by engrafted oNPCs, and neurobehavioral recovery.

Original language	English
Pages (from-to)	1433-1448
Number of pages	16
Journal	Stem Cell Reports
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/j.stemcr.2018.10.017
Publication status	Published - 2018 Dec 11

Keywords

cell transplantation
ChABC
chronic spinal cord injury
combinatorial therapy
crosslinked methylcellulose hydrogel
glial scar
neural progenitor cells
oligodendrocyte
regenerative medicine
remyelination

ASJC Scopus subject areas

Biochemistry
Genetics
Developmental Biology
Cell Biology

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Nori, S., Khazaei, M., Ahuja, C. S., Yokota, K., Ahlfors, J. E., Liu, Y., Wang, J., Shibata, S., Chio, J., Hettiaratchi, M. H., Führmann, T., Shoichet, M. S., & Fehlings, M. G. (2018). Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury. Stem Cell Reports, 11(6), 1433-1448. https://doi.org/10.1016/j.stemcr.2018.10.017

Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury. / Nori, Satoshi; Khazaei, Mohamad; Ahuja, Christopher S.; Yokota, Kazuya; Ahlfors, Jan Eric; Liu, Yang; Wang, Jian; Shibata, Shinsuke; Chio, Jonathon; Hettiaratchi, Marian H.; Führmann, Tobias; Shoichet, Molly S.; Fehlings, Michael G.

In: Stem Cell Reports, Vol. 11, No. 6, 11.12.2018, p. 1433-1448.

Research output: Contribution to journal › Article

Nori, S, Khazaei, M, Ahuja, CS, Yokota, K, Ahlfors, JE, Liu, Y, Wang, J, Shibata, S, Chio, J, Hettiaratchi, MH, Führmann, T, Shoichet, MS & Fehlings, MG 2018, 'Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury', Stem Cell Reports, vol. 11, no. 6, pp. 1433-1448. https://doi.org/10.1016/j.stemcr.2018.10.017

Nori, Satoshi ; Khazaei, Mohamad ; Ahuja, Christopher S. ; Yokota, Kazuya ; Ahlfors, Jan Eric ; Liu, Yang ; Wang, Jian ; Shibata, Shinsuke ; Chio, Jonathon ; Hettiaratchi, Marian H. ; Führmann, Tobias ; Shoichet, Molly S. ; Fehlings, Michael G. / Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury. In: Stem Cell Reports. 2018 ; Vol. 11, No. 6. pp. 1433-1448.

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