Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system.

K. Ueda, T. Saeki, M. Hirai, Y. Tanigawara, K. Tanaka, M. Okamura, M. Yasuhara, R. Hori, K. Inui, T. Komano

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15 Citations (Scopus)

Abstract

To analyze the mechanism of drug transport, mechanism of inhibitors, and physiological substrates of human P-glycoprotein, we established a transepithelial transport system by introducing MDR1 cDNA into LLC-PK1, a pig kidney epithelial cell line. P-glycoprotein functions as a steroid transporter as well as a drug transporter as physiological functions. P-glycoprotein also transports MDR modulators such as cyclosporin A, FK506, and calcium channel blockers.

Original languageEnglish
Pages (from-to)S67-71
JournalThe Japanese journal of physiology
Volume44 Suppl 2
Publication statusPublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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  • Cite this

    Ueda, K., Saeki, T., Hirai, M., Tanigawara, Y., Tanaka, K., Okamura, M., Yasuhara, M., Hori, R., Inui, K., & Komano, T. (1994). Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system. The Japanese journal of physiology, 44 Suppl 2, S67-71.