TY - JOUR
T1 - Human Papillomavirus Test for Triage of Japanese Women with Low-Grade Squamous Intraepithelial Lesions
AU - Iwata, Takashi
AU - Hasegawa, Toshihiko
AU - Ochiai, Kazunori
AU - Takizawa, Ken
AU - Umezawa, Satoshi
AU - Kuramoto, Hiroyuki
AU - Ohmura, Mineo
AU - Kubushiro, Kaneyuki
AU - Arai, Hiroharu
AU - Sakamoto, Masaru
AU - Motoyama, Teiichi
AU - Watanabe, Kayoko
AU - Aoki, Daisuke
PY - 2015/12/1
Y1 - 2015/12/1
N2 - We evaluated high-risk human papillomavirus (HR-HPV) DNA testing for high-grade cervical intraepithelial neoplasia (CIN) lesions by cobas HPV test and diagnostic HPV16/18 genotyping in Japanese women with low-grade squamous intraepithelial lesions. Of 357 patients, HR-HPV positivity prevalence was 75.6%, and 21.3% had grade 2 or higher CIN lesions (CIN2+), with the highest prevalence at 30 to 34 years. Negative predictive values of HR-HPV for CIN2+ in our patients were 93.1% (any age) and 94.9% (40-50 years). Absolute risk for CIN2+ in HR-HPV positive and HPV16/18 positive individuals was 25.9 and 35.1, respectively. Relative risk for CIN2+ lesions was 5.1 for HPV16/18 positive versus HR-HPV negative, and 3.8 for HR-HPV positive versus HR-HPV negative women. Predictive values of CIN2+ positive were higher for HPV16/18 positive women (any age) than 12 other HPV positive-genotypes, and highest (50%) at 40-50 years. The HPV16/18 genotyping might prevent women (>40 years) at risk of high-grade CIN lesions from undergoing unnecessary colposcopy/overtreatment of nonprogressive lesions.
AB - We evaluated high-risk human papillomavirus (HR-HPV) DNA testing for high-grade cervical intraepithelial neoplasia (CIN) lesions by cobas HPV test and diagnostic HPV16/18 genotyping in Japanese women with low-grade squamous intraepithelial lesions. Of 357 patients, HR-HPV positivity prevalence was 75.6%, and 21.3% had grade 2 or higher CIN lesions (CIN2+), with the highest prevalence at 30 to 34 years. Negative predictive values of HR-HPV for CIN2+ in our patients were 93.1% (any age) and 94.9% (40-50 years). Absolute risk for CIN2+ in HR-HPV positive and HPV16/18 positive individuals was 25.9 and 35.1, respectively. Relative risk for CIN2+ lesions was 5.1 for HPV16/18 positive versus HR-HPV negative, and 3.8 for HR-HPV positive versus HR-HPV negative women. Predictive values of CIN2+ positive were higher for HPV16/18 positive women (any age) than 12 other HPV positive-genotypes, and highest (50%) at 40-50 years. The HPV16/18 genotyping might prevent women (>40 years) at risk of high-grade CIN lesions from undergoing unnecessary colposcopy/overtreatment of nonprogressive lesions.
KW - cervical intraepithelial neoplasia
KW - cobas HPV test
KW - high-risk human papillomavirus
KW - low-grade squamous intraepithelial lesions
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U2 - 10.1177/1933719115589408
DO - 10.1177/1933719115589408
M3 - Article
C2 - 26092278
AN - SCOPUS:84947060664
SN - 1933-7191
VL - 22
SP - 1509
EP - 1515
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 12
ER -