Human papillomavirus type 18 DNA AND E6-E7 mRNA are detected in squamous cell carcinoma and adenocarcinoma of the lung

I. Kinoshita; H. Dosaka-Akita; M. Shindoh; M. Fujino; K. Akie; M. Kato; K. Fujinaga; Y. Kawakami

doi:10.1038/bjc.1995.69

Human papillomavirus type 18 DNA AND E6-E7 mRNA are detected in squamous cell carcinoma and adenocarcinoma of the lung

I. Kinoshita, H. Dosaka-Akita, M. Shindoh, M. Fujino, K. Akie, M. Kato, K. Fujinaga, Y. Kawakami

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

To provide an accurate evaluation of the association of human papillomavirus (HPV) with lung cancer, 36 cases of lung cancer were analysed for HPV DNAs by polymerase chain reaction (PCR) with dot-blot and Southern blot analyses, and for the transcripts from the E6-E7 transforming region by in situ hybridisation (ISH). HPV-18 DNA was detected in three (8%) of 36 specimens; histologically, in one (10%) of 10 squamous cell carcinomas and two (9%) of 22 adenocarcinomas. Neither HPV-16 nor -33 DNA was detected in any cases examined. Expression of E6-E7 mRNA was confirmed in the cases which contained, HPV-18 DNA. HPV-18 may play an important role in the development and progression of cancer in some cases of both squamous cell carcinoma and adenocarcinoma of the lung.

Original language	English
Pages (from-to)	344-349
Number of pages	6
Journal	British Journal of Cancer
Volume	71
Issue number	2
DOIs	https://doi.org/10.1038/bjc.1995.69
Publication status	Published - 1995 Feb
Externally published	Yes

Keywords

HPV
ISH
Lung cancer
PCR

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/bjc.1995.69

Cite this

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title = "Human papillomavirus type 18 DNA AND E6-E7 mRNA are detected in squamous cell carcinoma and adenocarcinoma of the lung",

abstract = "To provide an accurate evaluation of the association of human papillomavirus (HPV) with lung cancer, 36 cases of lung cancer were analysed for HPV DNAs by polymerase chain reaction (PCR) with dot-blot and Southern blot analyses, and for the transcripts from the E6-E7 transforming region by in situ hybridisation (ISH). HPV-18 DNA was detected in three (8%) of 36 specimens; histologically, in one (10%) of 10 squamous cell carcinomas and two (9%) of 22 adenocarcinomas. Neither HPV-16 nor -33 DNA was detected in any cases examined. Expression of E6-E7 mRNA was confirmed in the cases which contained, HPV-18 DNA. HPV-18 may play an important role in the development and progression of cancer in some cases of both squamous cell carcinoma and adenocarcinoma of the lung.",

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AU - Kinoshita, I.

AU - Dosaka-Akita, H.

AU - Shindoh, M.

AU - Fujino, M.

AU - Akie, K.

AU - Kato, M.

AU - Fujinaga, K.

AU - Kawakami, Y.

PY - 1995/2

Y1 - 1995/2

N2 - To provide an accurate evaluation of the association of human papillomavirus (HPV) with lung cancer, 36 cases of lung cancer were analysed for HPV DNAs by polymerase chain reaction (PCR) with dot-blot and Southern blot analyses, and for the transcripts from the E6-E7 transforming region by in situ hybridisation (ISH). HPV-18 DNA was detected in three (8%) of 36 specimens; histologically, in one (10%) of 10 squamous cell carcinomas and two (9%) of 22 adenocarcinomas. Neither HPV-16 nor -33 DNA was detected in any cases examined. Expression of E6-E7 mRNA was confirmed in the cases which contained, HPV-18 DNA. HPV-18 may play an important role in the development and progression of cancer in some cases of both squamous cell carcinoma and adenocarcinoma of the lung.

AB - To provide an accurate evaluation of the association of human papillomavirus (HPV) with lung cancer, 36 cases of lung cancer were analysed for HPV DNAs by polymerase chain reaction (PCR) with dot-blot and Southern blot analyses, and for the transcripts from the E6-E7 transforming region by in situ hybridisation (ISH). HPV-18 DNA was detected in three (8%) of 36 specimens; histologically, in one (10%) of 10 squamous cell carcinomas and two (9%) of 22 adenocarcinomas. Neither HPV-16 nor -33 DNA was detected in any cases examined. Expression of E6-E7 mRNA was confirmed in the cases which contained, HPV-18 DNA. HPV-18 may play an important role in the development and progression of cancer in some cases of both squamous cell carcinoma and adenocarcinoma of the lung.

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KW - ISH

KW - Lung cancer

KW - PCR

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Human papillomavirus type 18 DNA AND E6-E7 mRNA are detected in squamous cell carcinoma and adenocarcinoma of the lung

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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