Human pathological basis of blood vessels and stromal tissue for nanotechnology

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

The recent development of nanotechnology has already produced clinically applicable "nanodrugs," which are largely dependent on a novel concept for the drug delivery system. Thus the elucidation of local pharmacokinetics of nanodrugs is indispensable for the further development of nanomedicine; however, the detailed pathophysiology associated with nano-sized materials especially in pathologic lesions has not been well-described. In this review article, the microscopic appearance of vascular pericytes in addition to endothelial cells is discussed in the normal state and also in several pathological conditions which could be the major targets for nanomedicine. Moreover, the role of stromal tissue including myofibroblasts is also focused on, as well as inflammatory cells. Finally, the significance of disease-specific tissue structure in the establishment of personalized nanomedicine is discussed.

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalAdvanced Drug Delivery Reviews
Volume74
DOIs
Publication statusPublished - 2014 Jul 30
Externally publishedYes

Fingerprint

Nanomedicine
Nanotechnology
Blood Vessels
Pericytes
Myofibroblasts
Drug Delivery Systems
Endothelial Cells
Pharmacokinetics

Keywords

  • Blood vessels
  • Histopathology
  • Myofibroblasts
  • Pericytes
  • Personalized nanomedicine
  • Stromal tissue
  • Vascular structure

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Human pathological basis of blood vessels and stromal tissue for nanotechnology. / Nishihara, Hiroshi.

In: Advanced Drug Delivery Reviews, Vol. 74, 30.07.2014, p. 19-27.

Research output: Contribution to journalReview article

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