Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging

Eishun Tsuchida, Teruyuki Komatsu, Yasuko Matsukawa, Akito Nakagawa, Hiromi Sakai, Koichi Kobayashi, Makoto Suematsu

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The administration of extracellular, hemoglobin-based oxygen carriers often elicits an acute increase in blood pressure by vasoconstriction. This side effect is now recognized to be due to the depletion of nitric oxide (endothelial-derived relaxing factor) by the extravasuated hemoglobins. We have recently found that the administration of a recombinant human serum albumin (rHSA)-based oxygen carrier involving synthetic tetraphenyporphinatoiron(II) derivative (FeP) (rHSA-FeP) does not induce such hypertensive action, because of its low permeability through the vascular endothelium. The heart rate responses after the rHSA-FeP injection were also negligibly small. Visualization of the intestinal microcirculatory changes clearly revealed the widths of the venule and arteriole to be fairly constant. The entirely synthetic rHSA-FeP becomes a promising material as a new type of red blood cell substitute.

Original languageEnglish
Pages (from-to)257-261
Number of pages5
JournalJournal of Biomedical Materials Research - Part A
Volume64
Issue number2
DOIs
Publication statusPublished - 2003 Feb 1

Keywords

  • Human serum albumin
  • Hypertension
  • Nitric oxide
  • Red blood cell substitute
  • Synthetic heme

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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