Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain

Masaki Kato, Kazuo Okanoya, Taku Koike, Erika Sasaki, Hideyuki Okano, Shigeru Watanabe, Atsushi Iriki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Language is a characteristic feature of human communication. Several familial language impairments have been identified, and candidate genes for language impairments already isolated. Studies comparing expression patterns of these genes in human brain are necessary to further understanding of these genes. However, it is difficult to examine gene expression in human brain. In this study, we used a non-human primate (common marmoset; Callithrix jacchus) as a biological model of the human brain to investigate expression patterns of human speech- and reading-related genes. Expression patterns of speech disorder- (FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed. We found the genes displayed overlapping expression patterns in the ocular, auditory, and motor systems. Our results enhance understanding of the molecular mechanisms underlying language impairments.

Original languageEnglish
Pages (from-to)26-38
Number of pages13
JournalBrain and Language
Volume133
DOIs
Publication statusPublished - 2014

Fingerprint

Callithrix
Reading
brain
Language
Brain
language
Genes
Overlapping Genes
dyslexia
speech disorder
Gene Expression
Speech Disorders
Biological Models
Dyslexia
candidacy
Primates
Communication
Gene
Human Speech
communication

Keywords

  • Common marmoset
  • Dyslexia
  • Gene expression
  • Language
  • Specific language impairment
  • Vocal communication

ASJC Scopus subject areas

  • Linguistics and Language
  • Speech and Hearing
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Language and Linguistics
  • Medicine(all)

Cite this

Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain. / Kato, Masaki; Okanoya, Kazuo; Koike, Taku; Sasaki, Erika; Okano, Hideyuki; Watanabe, Shigeru; Iriki, Atsushi.

In: Brain and Language, Vol. 133, 2014, p. 26-38.

Research output: Contribution to journalArticle

Kato, Masaki ; Okanoya, Kazuo ; Koike, Taku ; Sasaki, Erika ; Okano, Hideyuki ; Watanabe, Shigeru ; Iriki, Atsushi. / Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain. In: Brain and Language. 2014 ; Vol. 133. pp. 26-38.
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