Human tumor antigens recognized by T cells

Paul F. Robbins, Yutaka Kawakami

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

The ability of tumor-reactive T cells to mediate in vivo tumor regression has been demonstrated in murine tumor models and by the clinical responses to adoptive immunotherapy with tumor-infiltrating lymphocytes isolated from human melanomas. Investigations carried out in the past several years have resulted in the isolation of a number of the genes encoding antigens recognized by melanoma-reactive T cells. The ability of these products to serve as tumor regression antigens has now begun to be evaluated in clinical vaccine trials.

Original languageEnglish
Pages (from-to)628-636
Number of pages9
JournalCurrent Opinion in Immunology
Volume8
Issue number5
DOIs
Publication statusPublished - 1996 Oct

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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