Human tumor antigens recognized by T-cells

Yutaka Kawakami, Steven A. Rosenberg

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

T-cells play an important role in in vivo tumor rejection in many animal tumor models and in human melanoma. Many human tumor antigens recognized by autologous T-cells have now been identified. These are found to be nonmutated and mutated peptides derived from various self proteins as well as viral proteins. A variety of mechanisms involved in generating these T-cell epitopes on growing cancers have also been identified. However, the role of these identified antigens remains to be evaluated. Passive or active immunotherapies using these identified tumor antigens are being conducted in many institutions. The results obtained from these clinical trials may give us better insight into the role of T-cell responses to each antigen in tumor rejection as well as the development of new antigen-specific immunotherapies for patients with cancer.

Original languageEnglish
Pages (from-to)313-339
Number of pages27
JournalImmunologic Research
Volume16
Issue number4
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Neoplasm Antigens
T-Lymphocytes
Neoplasms
Antigens
Active Immunotherapy
T-Lymphocyte Epitopes
Passive Immunization
Viral Proteins
Immunotherapy
Melanoma
Animal Models
Clinical Trials
Peptides
Proteins

Keywords

  • Immunotherapy
  • T-cells
  • Tolerance
  • Tumor antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Kawakami, Y., & Rosenberg, S. A. (1997). Human tumor antigens recognized by T-cells. Immunologic Research, 16(4), 313-339.

Human tumor antigens recognized by T-cells. / Kawakami, Yutaka; Rosenberg, Steven A.

In: Immunologic Research, Vol. 16, No. 4, 1997, p. 313-339.

Research output: Contribution to journalArticle

Kawakami, Y & Rosenberg, SA 1997, 'Human tumor antigens recognized by T-cells', Immunologic Research, vol. 16, no. 4, pp. 313-339.
Kawakami Y, Rosenberg SA. Human tumor antigens recognized by T-cells. Immunologic Research. 1997;16(4):313-339.
Kawakami, Yutaka ; Rosenberg, Steven A. / Human tumor antigens recognized by T-cells. In: Immunologic Research. 1997 ; Vol. 16, No. 4. pp. 313-339.
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