Humanin affects object recognition and gliosis in short-term cuprizone-treated mice

Minetaka Murakami, Masatoshi Nagahama, Yoichiro Abe, Takako Niikura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Humanin (HN) is a 24-residue peptide that manipulates cell survival under various stresses. A highly potent HN derivative, HNG, reduced amyloid burden and neuroinflammation and suppressed cognitive impairment in Alzheimer's disease model mice. Cuprizone (CPZ), a copper chelator, provokes demyelination in the central nervous system of mice. A shorter (one week) exposure to CPZ induces schizophrenia-like behavior and glial activation prior to demyelination. We tested the effect of HNG on these short-term responses to CZP in mice. Intraperitoneal injection of HNG for one week improved object recognition memory but not working memory in CPZ-treated mice. Quantitative PCR analyses showed that HNG significantly suppressed CPZ-induced activation of microglia, but did not alter the reduced level of a myelin-specific transcript. These results suggest that HN can suppress neuroinflammation and the associated cognitive deficit in a wider range of neurological disorders beyond Alzheimer's disease.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalNeuropeptides
Volume66
DOIs
Publication statusPublished - 2017 Dec 1

Fingerprint

Cuprizone
Gliosis
Demyelinating Diseases
Alzheimer Disease
Neurologic Mutant Mice
Microglia
Chelating Agents
Myelin Sheath
Nervous System Diseases
Intraperitoneal Injections
Short-Term Memory
Amyloid
Neuroglia
Copper
Cell Survival
Schizophrenia
Central Nervous System
Polymerase Chain Reaction
Peptides
Recognition (Psychology)

Keywords

  • Amnesia
  • Cuprizone
  • Humanin
  • Neuroinflammation

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Humanin affects object recognition and gliosis in short-term cuprizone-treated mice. / Murakami, Minetaka; Nagahama, Masatoshi; Abe, Yoichiro; Niikura, Takako.

In: Neuropeptides, Vol. 66, 01.12.2017, p. 90-96.

Research output: Contribution to journalArticle

Murakami, Minetaka ; Nagahama, Masatoshi ; Abe, Yoichiro ; Niikura, Takako. / Humanin affects object recognition and gliosis in short-term cuprizone-treated mice. In: Neuropeptides. 2017 ; Vol. 66. pp. 90-96.
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