Humanin

After the discovery

Takako Niikura, Tomohiro Chiba, Sadakazu Aiso, Masaaki Matsuoka, Ikuo Nishimoto

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Humanin (HN) is a novel neuroprotective factor that consists of 24 amino acid residues. HN suppresses neuronal cell death caused by Alzheimer's disease (AD)-specific insults, including both amyloid-β (βAβ) peptides and familial AD-causative genes. Cerebrovascular smooth muscle cells are also protected from Aβ toxicity by HN, suggesting that HN affects both neuronal and non-neuronal cells when they are exposed to AD-related cytotoxicity. HN peptide exerts a neuroprotective effect through the cell surface via putative receptor(s). HN activates a cellular signaling cascade that intervenes (at least) in activation of c-Jun N-terminal kinase. The highly selective effect of HN on AD-relevant cell death indicates that HN is promising for AD therapy. Additionally, a recent study showed that intracellularly overexpressed HN suppressed mitochondriamediated apoptosis by inhibiting Bax activity.

Original languageEnglish
Pages (from-to)327-340
Number of pages14
JournalMolecular Neurobiology
Volume30
Issue number3
DOIs
Publication statusPublished - 2004 Dec

Fingerprint

Alzheimer Disease
Cell Death
humanin
Peptides
JNK Mitogen-Activated Protein Kinases
Neuroprotective Agents
Amyloid
Smooth Muscle Myocytes
Apoptosis
Amino Acids
Genes
Therapeutics

Keywords

  • AβPP
  • Alzheimer's disease
  • Amyloid β
  • Cell death
  • Humanin
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Niikura, T., Chiba, T., Aiso, S., Matsuoka, M., & Nishimoto, I. (2004). Humanin: After the discovery. Molecular Neurobiology, 30(3), 327-340. https://doi.org/10.1385/MN:30:3:327

Humanin : After the discovery. / Niikura, Takako; Chiba, Tomohiro; Aiso, Sadakazu; Matsuoka, Masaaki; Nishimoto, Ikuo.

In: Molecular Neurobiology, Vol. 30, No. 3, 12.2004, p. 327-340.

Research output: Contribution to journalArticle

Niikura, T, Chiba, T, Aiso, S, Matsuoka, M & Nishimoto, I 2004, 'Humanin: After the discovery', Molecular Neurobiology, vol. 30, no. 3, pp. 327-340. https://doi.org/10.1385/MN:30:3:327
Niikura T, Chiba T, Aiso S, Matsuoka M, Nishimoto I. Humanin: After the discovery. Molecular Neurobiology. 2004 Dec;30(3):327-340. https://doi.org/10.1385/MN:30:3:327
Niikura, Takako ; Chiba, Tomohiro ; Aiso, Sadakazu ; Matsuoka, Masaaki ; Nishimoto, Ikuo. / Humanin : After the discovery. In: Molecular Neurobiology. 2004 ; Vol. 30, No. 3. pp. 327-340.
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