Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

Yoshifumi Uwamino; Takashi Yokoyama; Yasunori Sato; Ayako Shibata; Toshinobu Kurafuji; Akiko Tanabe; Masayo Noguchi; Tomoko Arai; Akemi Ohno; Hiromitsu Yokota; Ho Namkoong; Tomoyasu Nishimura; Kenjiro Kosaki; Naoki Hasegawa; Masatoshi Wakui; Mitsuru Murata; Hiromichi Matsushita

doi:10.1016/j.vaccine.2023.01.049

Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

Yoshifumi Uwamino, Takashi Yokoyama, Yasunori Sato, Ayako Shibata, Toshinobu Kurafuji, Akiko Tanabe, Masayo Noguchi, Tomoko Arai, Akemi Ohno, Hiromitsu Yokota, Ho Namkoong, Tomoyasu Nishimura, Kenjiro Kosaki, Naoki Hasegawa, Masatoshi Wakui, Mitsuru Murata, Hiromichi Matsushita

Research output: Contribution to journal › Article › peer-review

Abstract

Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.

Original language	English
Pages (from-to)	1545-1549
Number of pages	5
Journal	Vaccine
Volume	41
Issue number	9
DOIs	https://doi.org/10.1016/j.vaccine.2023.01.049
Publication status	Published - 2023 Feb 24

Keywords

Antibody
BNT162b2
COVID-19 vaccine
Cellular immunity
Third dose

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.vaccine.2023.01.049

Cite this

Uwamino, Y., Yokoyama, T., Sato, Y., Shibata, A., Kurafuji, T., Tanabe, A., Noguchi, M., Arai, T., Ohno, A., Yokota, H., Namkoong, H., Nishimura, T., Kosaki, K., Hasegawa, N., Wakui, M., Murata, M., & Matsushita, H. (2023). Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine. Vaccine, 41(9), 1545-1549. https://doi.org/10.1016/j.vaccine.2023.01.049

Uwamino, Y, Yokoyama, T, Sato, Y, Shibata, A, Kurafuji, T, Tanabe, A, Noguchi, M, Arai, T, Ohno, A, Yokota, H, Namkoong, H, Nishimura, T, Kosaki, K, Hasegawa, N, Wakui, M, Murata, M & Matsushita, H 2023, 'Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine', Vaccine, vol. 41, no. 9, pp. 1545-1549. https://doi.org/10.1016/j.vaccine.2023.01.049

@article{9fe0a680bd49478f84716b456d56fb99,

title = "Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine",

abstract = "Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.",

keywords = "Antibody, BNT162b2, COVID-19 vaccine, Cellular immunity, Third dose",

author = "Yoshifumi Uwamino and Takashi Yokoyama and Yasunori Sato and Ayako Shibata and Toshinobu Kurafuji and Akiko Tanabe and Masayo Noguchi and Tomoko Arai and Akemi Ohno and Hiromitsu Yokota and Ho Namkoong and Tomoyasu Nishimura and Kenjiro Kosaki and Naoki Hasegawa and Masatoshi Wakui and Mitsuru Murata and Hiromichi Matsushita",

note = "Funding Information: This work was supported by the Japan Agency for Medical Research and Development [grant number: JP21fk0108469], the Keio University School of Medicine, and the Public Foundation of the Vaccination Research Center, Japan. Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = feb,

day = "24",

doi = "10.1016/j.vaccine.2023.01.049",

language = "English",

volume = "41",

pages = "1545--1549",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

number = "9",

}

TY - JOUR

T1 - Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

AU - Uwamino, Yoshifumi

AU - Yokoyama, Takashi

AU - Sato, Yasunori

AU - Shibata, Ayako

AU - Kurafuji, Toshinobu

AU - Tanabe, Akiko

AU - Noguchi, Masayo

AU - Arai, Tomoko

AU - Ohno, Akemi

AU - Yokota, Hiromitsu

AU - Namkoong, Ho

AU - Nishimura, Tomoyasu

AU - Kosaki, Kenjiro

AU - Hasegawa, Naoki

AU - Wakui, Masatoshi

AU - Murata, Mitsuru

AU - Matsushita, Hiromichi

N1 - Funding Information: This work was supported by the Japan Agency for Medical Research and Development [grant number: JP21fk0108469], the Keio University School of Medicine, and the Public Foundation of the Vaccination Research Center, Japan. Publisher Copyright: © 2023 Elsevier Ltd

PY - 2023/2/24

Y1 - 2023/2/24

N2 - Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.

AB - Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.

KW - Antibody

KW - BNT162b2

KW - COVID-19 vaccine

KW - Cellular immunity

KW - Third dose

UR - http://www.scopus.com/inward/record.url?scp=85147226181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85147226181&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2023.01.049

DO - 10.1016/j.vaccine.2023.01.049

M3 - Article

AN - SCOPUS:85147226181

SN - 0264-410X

VL - 41

SP - 1545

EP - 1549

JO - Vaccine

JF - Vaccine

IS - 9

ER -

Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this