Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection

Tatsuya Dokoshi, Ling juan Zhang, Fengwu Li, Teruaki Nakatsuji, Anna Butcher, Hiroyuki Yoshida, Masayuki Shimoda, Yasunori Okada, Richard L. Gallo

Research output: Contribution to journalArticle

Abstract

In this paper, Dokoshi et al. describe how the mammalian hyaluronidase Cemip is induced in the dermis during S. aureus infection. Cemip digests hyaluronan in the skin to regulate reactive adipogenesis and subsequent antimicrobial activity and skin inflammation.

Original languageEnglish
Pages (from-to)61-68.e4
JournalCell Reports
Volume30
Issue number1
DOIs
Publication statusPublished - 2020 Jan 7

Keywords

  • Staphylococcus aureus
  • antimicrobial peptides
  • cathelicidin
  • dermis
  • glycosaminoglycans
  • hyaluronan
  • innate immunity
  • skin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Dokoshi, T., Zhang, L. J., Li, F., Nakatsuji, T., Butcher, A., Yoshida, H., Shimoda, M., Okada, Y., & Gallo, R. L. (2020). Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection. Cell Reports, 30(1), 61-68.e4. https://doi.org/10.1016/j.celrep.2019.12.001