Hydrophobicity and non-thrombogenicity of nanoscale dual rough surface coated with fluorine-incorporated diamond-like carbon films: Biomimetic surface for blood-contacting medical devices

Terumitsu Hasebe, So Nagashima, Aki Kamijo, Myoung Woon Moon, Yousuke Kashiwagi, Atsushi Hotta, Kwang Ryeol Lee, Koki Takahashi, Takuji Yamagami, Tetsuya Suzuki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We investigated the hydrophobicity and non-thrombogenicity of a nanoscale dual rough surface coated with hydrophobic and non-thrombogenic fluorine-incorporated diamond-like carbon (F-DLC) films. We prepared Si (1 0 0) and a dual rough surface composed of coarse posts and nano-sized fine posts as substrates. DLC film was deposited on the Si substrate, and F-DLC film was deposited on Si or the dual rough surface using radio frequency plasma enhanced chemical vapor deposition method. The surface hydrophobicity of each sample was examined with water contact angle measurements and the non-thrombogenicity was evaluated through incubation with platelet-rich plasma isolated from human whole blood. The water repellency was dramatically improved on the F-DLC-coated dual rough surface compared with that on DLC-coated Si or F-DLC-coated Si, which had a water contact angle of 130.6°. There was no significant difference in the values for the platelet-covered area between DLC-coated Si and the F-DLC-coated dual rough surface. As DLC is being considered for widespread clinical use as a surface coating for medical devices owing to its non-thrombogenicity compared with other biomaterials, the F-DLC-coated dual rough surface presented in this study still has the potential for clinical use, such as temporary blood-contacting medical devices, to take advantage of its high hydrophobicity.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalDiamond and Related Materials
Volume38
DOIs
Publication statusPublished - 2013

Fingerprint

Diamond like carbon films
Fluorine
biomimetics
Biomimetics
Hydrophobicity
hydrophobicity
blood
fluorine
Blood
diamonds
Diamond
carbon
Diamonds
Carbon
Platelets
platelets
Contact angle
Water
water
Biocompatible Materials

Keywords

  • Biomimetic surface
  • Diamond-like carbon
  • Hydrophobicity
  • Nanoscale dual rough surface
  • Non-thrombogenicity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Physics and Astronomy(all)
  • Chemistry(all)

Cite this

Hydrophobicity and non-thrombogenicity of nanoscale dual rough surface coated with fluorine-incorporated diamond-like carbon films : Biomimetic surface for blood-contacting medical devices. / Hasebe, Terumitsu; Nagashima, So; Kamijo, Aki; Moon, Myoung Woon; Kashiwagi, Yousuke; Hotta, Atsushi; Lee, Kwang Ryeol; Takahashi, Koki; Yamagami, Takuji; Suzuki, Tetsuya.

In: Diamond and Related Materials, Vol. 38, 2013, p. 14-18.

Research output: Contribution to journalArticle

Hasebe, Terumitsu ; Nagashima, So ; Kamijo, Aki ; Moon, Myoung Woon ; Kashiwagi, Yousuke ; Hotta, Atsushi ; Lee, Kwang Ryeol ; Takahashi, Koki ; Yamagami, Takuji ; Suzuki, Tetsuya. / Hydrophobicity and non-thrombogenicity of nanoscale dual rough surface coated with fluorine-incorporated diamond-like carbon films : Biomimetic surface for blood-contacting medical devices. In: Diamond and Related Materials. 2013 ; Vol. 38. pp. 14-18.
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AU - Nagashima, So

AU - Kamijo, Aki

AU - Moon, Myoung Woon

AU - Kashiwagi, Yousuke

AU - Hotta, Atsushi

AU - Lee, Kwang Ryeol

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AU - Suzuki, Tetsuya

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AB - We investigated the hydrophobicity and non-thrombogenicity of a nanoscale dual rough surface coated with hydrophobic and non-thrombogenic fluorine-incorporated diamond-like carbon (F-DLC) films. We prepared Si (1 0 0) and a dual rough surface composed of coarse posts and nano-sized fine posts as substrates. DLC film was deposited on the Si substrate, and F-DLC film was deposited on Si or the dual rough surface using radio frequency plasma enhanced chemical vapor deposition method. The surface hydrophobicity of each sample was examined with water contact angle measurements and the non-thrombogenicity was evaluated through incubation with platelet-rich plasma isolated from human whole blood. The water repellency was dramatically improved on the F-DLC-coated dual rough surface compared with that on DLC-coated Si or F-DLC-coated Si, which had a water contact angle of 130.6°. There was no significant difference in the values for the platelet-covered area between DLC-coated Si and the F-DLC-coated dual rough surface. As DLC is being considered for widespread clinical use as a surface coating for medical devices owing to its non-thrombogenicity compared with other biomaterials, the F-DLC-coated dual rough surface presented in this study still has the potential for clinical use, such as temporary blood-contacting medical devices, to take advantage of its high hydrophobicity.

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