Hydrothermal Preparation of Granular Hydroxyapatite with Controlled Surface

Koji Ioku, Manami Toda, Hirotaka Fujimori, Seishi Goto, Masahiro Yoshimura

Research output: Contribution to journalConference articlepeer-review

14 Citations (Scopus)


Microstructure designed hydroxyapatite granules from about 50 μm to 1 mm in size were prepared by hydrothermal vapor exposure method at temperatures from 105 °C to 250 °C under the saturated vapor pressure of pure water. As starting materials, powder of α-tricalcium phosphate, gelatin and a vegetable oil were used. The size of granules, the shape of particles in the granules, and the microporosity of about 0.1 μm in size of the granules were controlled. The granular hydroxyapatite prepared at 200 °C under the saturated vapor pressure of pure water for 20 h was composed of rod-shaped crystals of about 40 μm in length with mean aspect ratio of 50. Rod-shaped hydroxyapatite crystals were locked together to make micropores of about 0.1 μm in size. It was non-stoichiometric hydroxyapatite with calcium deficient composition. This granular hydroxyapatite should have the advantage of adsorptive activity, because it has large specific crystal surface and micropores.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2004 Jan 1
Externally publishedYes
EventThe Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal
Duration: 2003 Nov 62003 Nov 9


  • Granule
  • Hydrothermal
  • Mydroxyapatite
  • Porous Ceramics

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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