Hyperfractionated radiation therapy for locoregionally advanced nasopharyngeal cancer

Koichi Isobe, Takashi Uno, Hiroyuki Kawakami, Naoyuki Ueno, Takashi Aruga, Shigeo Yasuda, Toyoyuki Hanazawa, Yoshitaka Okamoto, Hisao Ito, Naoyuki Shigematsu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objective: The purpose of this study is to clarify the efficacy and toxicity of hyperfractionated radiation therapy (RT) for patients with nasopharyngeal cancer (NPC). Methods: Twenty-two patients with NPC treated at our hospital between April 1994 and December 2002 were the subjects of this study. They received hyperfractionated RT with a fraction size of 1.2 Gy, with a median tumor dose of 72 Gy (range 64.8-80.4). During this study period, our institutional strategy for locoregionally advanced NPC included neoadjuvant or concurrent chemotherapy combined with hyperfractionated RT, and 17 patients received some forms of cisplatin-containing chemotherapy. Results: With a median follow-up of 59 months, the estimated 5-year disease-free survival rate and overall survival rate were 72.7 and 85.2%, respectively. Acute hematological toxicities were acceptable and manageable. However, >50% of patients required nutritional support, and experienced severe pharyngitis, skin reaction and body weight loss. With regard to late sequelae, one patient developed grade 3 osteomyelitis, and one patient each developed grade 4 passage disturbance and laryngeal edema. No patients experienced any grades of optic nerve injury or temporal lobe necrosis. Conclusions: Hyperfractionated RT using 1.2 Gy per fraction, for a total dose of 72 Gy, produces a comparable treatment outcome. Although deleterious neurological sequelae were not observed in this study, caution should be exercised regarding other late sequelae, such as osteomyelitis and passage disturbance.

Original languageEnglish
Pages (from-to)116-120
Number of pages5
JournalJapanese journal of clinical oncology
Issue number3
Publication statusPublished - 2005 Mar


  • Altered fractionation
  • Hyperfractionation
  • Late effect
  • Nasopharyngeal cancer (NPC)

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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