Hypergonadotropic hypogonadism in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome

Tsutomu Ogata; Tomonobu Hasegawa; Shinya Tamai; Seiji Sato; Yukihiro Hasegawa; Nobutake Matsuo

doi:10.1159/000023272

Hypergonadotropic hypogonadism in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome

Tsutomu Ogata, Tomonobu Hasegawa, Shinya Tamai, Seiji Sato, Yukihiro Hasegawa, Nobutake Matsuo

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We report on ovarian dysfunction in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). A gonadotropin releasing hormone test showed hyperresponses of luteinizing hormone (< 0.2→7.2 mIU/ml) and follicle-stimulating hormone (7.1→44.8 mIU/ml), and a human menopause gonadotropin test yielded no estradiol response (13→11 pg/ml). The results suggest that primary ovarian failure in type I BPES can take place in early childhood.

Original language	English
Pages (from-to)	190-192
Number of pages	3
Journal	Hormone Research
Volume	50
Issue number	3
DOIs	https://doi.org/10.1159/000023272
Publication status	Published - 1998 Sept 1

Keywords

Blepharophimosis
Childhood
Hypergonadotropic hypogonadism
Ovarian failure

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000023272

Cite this

@article{9f6f3926a3e54abeb0a1667b39cba08e,

title = "Hypergonadotropic hypogonadism in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome",

abstract = "We report on ovarian dysfunction in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). A gonadotropin releasing hormone test showed hyperresponses of luteinizing hormone (< 0.2→7.2 mIU/ml) and follicle-stimulating hormone (7.1→44.8 mIU/ml), and a human menopause gonadotropin test yielded no estradiol response (13→11 pg/ml). The results suggest that primary ovarian failure in type I BPES can take place in early childhood.",

keywords = "Blepharophimosis, Childhood, Hypergonadotropic hypogonadism, Ovarian failure",

author = "Tsutomu Ogata and Tomonobu Hasegawa and Shinya Tamai and Seiji Sato and Yukihiro Hasegawa and Nobutake Matsuo",

year = "1998",

month = sep,

day = "1",

doi = "10.1159/000023272",

language = "English",

volume = "50",

pages = "190--192",

journal = "Steroids and lipids research",

issn = "1663-2818",

publisher = "S. Karger AG",

number = "3",

}

TY - JOUR

T1 - Hypergonadotropic hypogonadism in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome

AU - Ogata, Tsutomu

AU - Hasegawa, Tomonobu

AU - Tamai, Shinya

AU - Sato, Seiji

AU - Hasegawa, Yukihiro

AU - Matsuo, Nobutake

PY - 1998/9/1

Y1 - 1998/9/1

N2 - We report on ovarian dysfunction in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). A gonadotropin releasing hormone test showed hyperresponses of luteinizing hormone (< 0.2→7.2 mIU/ml) and follicle-stimulating hormone (7.1→44.8 mIU/ml), and a human menopause gonadotropin test yielded no estradiol response (13→11 pg/ml). The results suggest that primary ovarian failure in type I BPES can take place in early childhood.

AB - We report on ovarian dysfunction in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). A gonadotropin releasing hormone test showed hyperresponses of luteinizing hormone (< 0.2→7.2 mIU/ml) and follicle-stimulating hormone (7.1→44.8 mIU/ml), and a human menopause gonadotropin test yielded no estradiol response (13→11 pg/ml). The results suggest that primary ovarian failure in type I BPES can take place in early childhood.

KW - Blepharophimosis

KW - Childhood

KW - Hypergonadotropic hypogonadism

KW - Ovarian failure

UR - http://www.scopus.com/inward/record.url?scp=0031686450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031686450&partnerID=8YFLogxK

U2 - 10.1159/000023272

DO - 10.1159/000023272

M3 - Article

C2 - 9762009

AN - SCOPUS:0031686450

SN - 1663-2818

VL - 50

SP - 190

EP - 192

JO - Steroids and lipids research

JF - Steroids and lipids research

IS - 3

ER -

Hypergonadotropic hypogonadism in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this