Hypergonadotropic hypogonadism in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome

Tsutomu Ogata, Tomonobu Hasegawa, Shinya Tamai, Seiji Sato, Yukihiro Hasegawa, Nobutake Matsuo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report on ovarian dysfunction in a 3-year-old girl with blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). A gonadotropin releasing hormone test showed hyperresponses of luteinizing hormone (< 0.2→7.2 mIU/ml) and follicle-stimulating hormone (7.1→44.8 mIU/ml), and a human menopause gonadotropin test yielded no estradiol response (13→11 pg/ml). The results suggest that primary ovarian failure in type I BPES can take place in early childhood.

Original languageEnglish
Pages (from-to)190-192
Number of pages3
JournalHormone Research
Volume50
Issue number3
DOIs
Publication statusPublished - 1998 Sep 1

Keywords

  • Blepharophimosis
  • Childhood
  • Hypergonadotropic hypogonadism
  • Ovarian failure

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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