Hyperplasia suppression by Ho

YAG laser intravascular irradiation in rabbit

Eriko Nakatani, Tsunenori Arai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The proliferation of smooth muscle cells (SMCs) was suppressed in denudated rabbit aorta by holmium-yttrium-aluminum-garnet (Ho:YAG) laser intravascular irradiation. This study was dedicated to determine the applicability of the Ho:YAG laser irradiation on chronic restenosis after balloon angioplasty. The proliferation of SMCs in denudated rabbit aortas was suppressed in vivo 6 weeks after the laser irradiation of 20 pulses with 60 mJ per pulse. To investigate the mechanisms of this in vivo effect, the death of SMCs by the Ho:YAG laser-induced bubble collapse pressure was studied in vitro. No significant cell death attributed to this pressure was found. We conclude that the suppression of the proliferation of SMCs in vivo might not be caused by a reduction in density of SMCs induced by the collapse in pressure. We submit that the suppression of SMC proliferation in vivo could be caused by the bubble expansion pressure and/or heat induced by the laser irradiation.

Original languageEnglish
Pages (from-to)74-81
Number of pages8
JournalLasers in Medical Science
Volume21
Issue number2
DOIs
Publication statusPublished - 2006 Jul

Fingerprint

Solid-State Lasers
Smooth Muscle Myocytes
Hyperplasia
Holmium
Rabbits
Pressure
Aorta
Lasers
Balloon Angioplasty
Pulse
Cell Death
Hot Temperature
Cell Proliferation

Keywords

  • Angioplasty
  • Collapse pressure
  • Ho:YAG laser
  • Laser-induced bubble
  • Restenosis
  • Smooth muscle cell proliferation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Surgery

Cite this

Hyperplasia suppression by Ho : YAG laser intravascular irradiation in rabbit. / Nakatani, Eriko; Arai, Tsunenori.

In: Lasers in Medical Science, Vol. 21, No. 2, 07.2006, p. 74-81.

Research output: Contribution to journalArticle

Nakatani, Eriko ; Arai, Tsunenori. / Hyperplasia suppression by Ho : YAG laser intravascular irradiation in rabbit. In: Lasers in Medical Science. 2006 ; Vol. 21, No. 2. pp. 74-81.
@article{367a739b27f54bbb8b903d2604326909,
title = "Hyperplasia suppression by Ho: YAG laser intravascular irradiation in rabbit",
abstract = "The proliferation of smooth muscle cells (SMCs) was suppressed in denudated rabbit aorta by holmium-yttrium-aluminum-garnet (Ho:YAG) laser intravascular irradiation. This study was dedicated to determine the applicability of the Ho:YAG laser irradiation on chronic restenosis after balloon angioplasty. The proliferation of SMCs in denudated rabbit aortas was suppressed in vivo 6 weeks after the laser irradiation of 20 pulses with 60 mJ per pulse. To investigate the mechanisms of this in vivo effect, the death of SMCs by the Ho:YAG laser-induced bubble collapse pressure was studied in vitro. No significant cell death attributed to this pressure was found. We conclude that the suppression of the proliferation of SMCs in vivo might not be caused by a reduction in density of SMCs induced by the collapse in pressure. We submit that the suppression of SMC proliferation in vivo could be caused by the bubble expansion pressure and/or heat induced by the laser irradiation.",
keywords = "Angioplasty, Collapse pressure, Ho:YAG laser, Laser-induced bubble, Restenosis, Smooth muscle cell proliferation",
author = "Eriko Nakatani and Tsunenori Arai",
year = "2006",
month = "7",
doi = "10.1007/s10103-006-0376-z",
language = "English",
volume = "21",
pages = "74--81",
journal = "Lasers in Medical Science",
issn = "0268-8921",
publisher = "Springer London",
number = "2",

}

TY - JOUR

T1 - Hyperplasia suppression by Ho

T2 - YAG laser intravascular irradiation in rabbit

AU - Nakatani, Eriko

AU - Arai, Tsunenori

PY - 2006/7

Y1 - 2006/7

N2 - The proliferation of smooth muscle cells (SMCs) was suppressed in denudated rabbit aorta by holmium-yttrium-aluminum-garnet (Ho:YAG) laser intravascular irradiation. This study was dedicated to determine the applicability of the Ho:YAG laser irradiation on chronic restenosis after balloon angioplasty. The proliferation of SMCs in denudated rabbit aortas was suppressed in vivo 6 weeks after the laser irradiation of 20 pulses with 60 mJ per pulse. To investigate the mechanisms of this in vivo effect, the death of SMCs by the Ho:YAG laser-induced bubble collapse pressure was studied in vitro. No significant cell death attributed to this pressure was found. We conclude that the suppression of the proliferation of SMCs in vivo might not be caused by a reduction in density of SMCs induced by the collapse in pressure. We submit that the suppression of SMC proliferation in vivo could be caused by the bubble expansion pressure and/or heat induced by the laser irradiation.

AB - The proliferation of smooth muscle cells (SMCs) was suppressed in denudated rabbit aorta by holmium-yttrium-aluminum-garnet (Ho:YAG) laser intravascular irradiation. This study was dedicated to determine the applicability of the Ho:YAG laser irradiation on chronic restenosis after balloon angioplasty. The proliferation of SMCs in denudated rabbit aortas was suppressed in vivo 6 weeks after the laser irradiation of 20 pulses with 60 mJ per pulse. To investigate the mechanisms of this in vivo effect, the death of SMCs by the Ho:YAG laser-induced bubble collapse pressure was studied in vitro. No significant cell death attributed to this pressure was found. We conclude that the suppression of the proliferation of SMCs in vivo might not be caused by a reduction in density of SMCs induced by the collapse in pressure. We submit that the suppression of SMC proliferation in vivo could be caused by the bubble expansion pressure and/or heat induced by the laser irradiation.

KW - Angioplasty

KW - Collapse pressure

KW - Ho:YAG laser

KW - Laser-induced bubble

KW - Restenosis

KW - Smooth muscle cell proliferation

UR - http://www.scopus.com/inward/record.url?scp=33746288630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746288630&partnerID=8YFLogxK

U2 - 10.1007/s10103-006-0376-z

DO - 10.1007/s10103-006-0376-z

M3 - Article

VL - 21

SP - 74

EP - 81

JO - Lasers in Medical Science

JF - Lasers in Medical Science

SN - 0268-8921

IS - 2

ER -