Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients

Masahiro Nagao, Shuichi Kato, Hideaki Hayashi, Hidemi Misawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.

Original languageEnglish
Pages (from-to)557-560
Number of pages4
JournalActa Neuropathologica
Volume106
Issue number6
DOIs
Publication statusPublished - 2003 Dec 1
Externally publishedYes

Keywords

  • Anterior horn
  • Dendrite
  • Excitatory
  • Inhibitory
  • Regeneration

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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