Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients

Masahiro Nagao, Shuichi Kato, Hideaki Hayashi, Hidemi Misawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.

Original languageEnglish
Pages (from-to)557-560
Number of pages4
JournalActa Neuropathologica
Volume106
Issue number6
DOIs
Publication statusPublished - 2003 Dec
Externally publishedYes

Fingerprint

Myotonic Dystrophy
Duchenne Muscular Dystrophy
Motor Neurons
Synapses
Vesicular Acetylcholine Transport Proteins
R-SNARE Proteins
Synaptophysin
Nerve Regeneration
Antibodies
Carisoprodol
Muscular Diseases
Dendrites

Keywords

  • Anterior horn
  • Dendrite
  • Excitatory
  • Inhibitory
  • Regeneration

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients. / Nagao, Masahiro; Kato, Shuichi; Hayashi, Hideaki; Misawa, Hidemi.

In: Acta Neuropathologica, Vol. 106, No. 6, 12.2003, p. 557-560.

Research output: Contribution to journalArticle

@article{20d81633d161418f8b434a244705542b,
title = "Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients",
abstract = "Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.",
keywords = "Anterior horn, Dendrite, Excitatory, Inhibitory, Regeneration",
author = "Masahiro Nagao and Shuichi Kato and Hideaki Hayashi and Hidemi Misawa",
year = "2003",
month = "12",
doi = "10.1007/s00401-003-0759-1",
language = "English",
volume = "106",
pages = "557--560",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - Hyperproliferation of synapses on spinal motor neurons of Duchenne muscular dystrophy and myotonic dystrophy patients

AU - Nagao, Masahiro

AU - Kato, Shuichi

AU - Hayashi, Hideaki

AU - Misawa, Hidemi

PY - 2003/12

Y1 - 2003/12

N2 - Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.

AB - Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.

KW - Anterior horn

KW - Dendrite

KW - Excitatory

KW - Inhibitory

KW - Regeneration

UR - http://www.scopus.com/inward/record.url?scp=0344876032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344876032&partnerID=8YFLogxK

U2 - 10.1007/s00401-003-0759-1

DO - 10.1007/s00401-003-0759-1

M3 - Article

C2 - 12920538

AN - SCOPUS:0344876032

VL - 106

SP - 557

EP - 560

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 6

ER -