[Hypertension and arteriosclerosis].

Hiroyuki Sasamura, Hiroshi Itoh

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Hypertension is a known risk factor for arteriosclerosis, and causes both atherosclero= sis of medium-large arteries and arteriolosclerosis of the arterioles. Elevated blood pressure causes damage to the endothelium and vascular wall through both mechanical and humoral factors. We and others have shown that inhibition of the renin-angiotensin system at a 'critical period' during the development of hypertension results in a permanent suppression of hypertension in animal models. We have also reported that high-dose renin-angiotensin inhibition results in regression of hypertension, possibly by regression of renal arteriolar hypertrophy. These results suggest that understanding the process of arterial remodeling may play a key role in the development of new strategies for prevention and regression of hypertension and arteriosclerosis.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Volume69
Issue number1
Publication statusPublished - 2011 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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