Hypertrophic stimuli augment expression of cMG1/ERF-1, a putative zinc- finger motif transcription factor, in rat cardiomyocytes

Tomohiro Manabe, Keiichi Fukuda, Jing Pan, Koichi Nagasaki, Ken Yamaguchi, Satoshi Ogawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We isolated the gene for cMG1/ERF-1, a known putative zinc-finger transcription factor, by differential display of mRNA extracted from cardiomyocytes with and without leukemia inhibitory factor (LIF) stimulation. LIF induced cMG1/ERF-1 mRNA at 15 min, and levels peaked at 10-fold initial levels at 30 min. cMG1/ERF-1 expression was inhibited by AG490 (JAK2 inhibitor) and genistein, but was unaffected by PD98059 or wortmannin. Phenylephrine, angiotensin II and endothelin-1 also induced cMG1/ERF-1 expression. Mechanical stretch in vitro and acute pressure overload in vivo increased cMG1/ERF-1 expression. To our knowledge, this is the first report showing that the cMG1/ERF-1 gene can be induced by various hypertrophic stimuli, and that Janus kinase 2 is involved in this process.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalFEBS Letters
Volume463
Issue number1-2
DOIs
Publication statusPublished - 1999 Dec 10

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Keywords

  • Cardiac hypertrophy
  • Leukemia inhibitory factor
  • Rat cardiomyocyte
  • cMG1/ERF-1

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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