TY - JOUR
T1 - Hypocrellin B-based activatable photosensitizers for specific photodynamic effects against high H2O2-expressing cancer cells
AU - Kitamura, Takashi
AU - Nakata, Hirotaka
AU - Takahashi, Daisuke
AU - Toshima, Kazunobu
N1 - Funding Information:
This research was supported in part by the JSPS KAKENHI Grant Number JP19H02724 in Scientific Research (B), JP20J12227 in JSPS Fellows, the JST CREST Grant Number JPMJCR20R3, Keio University Academic Development Funds, and the Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research.
Publisher Copyright:
© The Royal Society of Chemistry 2021.
PY - 2022/1/7
Y1 - 2022/1/7
N2 - A novel tumor-related biomarker, a H2O2-activatable photosensitizer4based on the 1,3-dicarbonyl enol moieties of hypocrellin B (3), was designed and synthesized. The photosensitizer4showed a blue-shifted absorption band compared with3, and showed negligible photosensitizing ability without H2O2. However, the release of3from4by the reaction with H2O2regenerated the photosensitizing ability. Furthermore,4exhibited selective and effective photo-cytotoxicity against high H2O2-expressing cancer cells upon photo-irradiation with 660 nm light, which is inside the phototherapeutic window.
AB - A novel tumor-related biomarker, a H2O2-activatable photosensitizer4based on the 1,3-dicarbonyl enol moieties of hypocrellin B (3), was designed and synthesized. The photosensitizer4showed a blue-shifted absorption band compared with3, and showed negligible photosensitizing ability without H2O2. However, the release of3from4by the reaction with H2O2regenerated the photosensitizing ability. Furthermore,4exhibited selective and effective photo-cytotoxicity against high H2O2-expressing cancer cells upon photo-irradiation with 660 nm light, which is inside the phototherapeutic window.
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U2 - 10.1039/d1cc05823a
DO - 10.1039/d1cc05823a
M3 - Article
C2 - 34850796
AN - SCOPUS:85122044287
VL - 58
SP - 242
EP - 245
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 2
ER -