Hypocrellin B-based activatable photosensitizers for specific photodynamic effects against high H2O2-expressing cancer cells

Takashi Kitamura, Hirotaka Nakata, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A novel tumor-related biomarker, a H2O2-activatable photosensitizer4based on the 1,3-dicarbonyl enol moieties of hypocrellin B (3), was designed and synthesized. The photosensitizer4showed a blue-shifted absorption band compared with3, and showed negligible photosensitizing ability without H2O2. However, the release of3from4by the reaction with H2O2regenerated the photosensitizing ability. Furthermore,4exhibited selective and effective photo-cytotoxicity against high H2O2-expressing cancer cells upon photo-irradiation with 660 nm light, which is inside the phototherapeutic window.

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalChemical Communications
Volume58
Issue number2
DOIs
Publication statusPublished - 2022 Jan 7

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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