Hyponatremia, hypophosphatemia, and hypouricemia in a girl with macrophage activation syndrome

Kazuki Yamazawa, Kazuki Kodo, Jun Maeda, Sayu Omori, Mariko Hida, Tetsuya Mori, Midori Awazu

Research output: Contribution to journalArticle

9 Citations (Scopus)


Macrophage activation syndrome, a life-threatening complication of rheumatic disorders, is accompanied by the overproduction of cytokines. We describe a girl with macrophage activation syndrome complicating systemic-onset juvenile arthritis who developed hyponatremia, hypophosphatemia, and hypouricemia associated with a high level of serum tumor necrosis factor α. Renal proximal tubule dysfunction was considered to be the cause, which may be attributable to tumor necrosis factor α.

Original languageEnglish
Pages (from-to)2557-2560
Number of pages4
Issue number6
Publication statusPublished - 2006 Dec 1



  • Hemophagocytic lymphohistiocytosis
  • Hypophosphatemia
  • Renal impairment
  • Sodium

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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