Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm

Hiroki Tanaka, Nobuhiro Zaima, Takeshi Sasaki, Masaki Sano, Naoto Yamamoto, Takaaki Saito, Kazunori Inuzuka, Takahiro Hayasaka, Naoko Goto-Inoue, Yuki Sugiura, Kohji Sato, Hirona Kugo, Tatsuya Moriyama, Hiroyuki Konno, Mitsutoshi Setou, Naoki Unno

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The aortic wall is perfused by the adventitial vasa vasorum (VV). Tissue hypoxia has previously been observed as a manifestation of enlarged abdominal aortic aneurysms (AAAs). We sought to determine whether hypoperfusion of the adventitial VV could develop AAAs. We created a novel animal model of adventitial VV hypoperfusion with a combination of a polyurethane catheter insertion and a suture ligation of the infrarenal abdominal aorta in rats. VV hypoperfusion caused tissue hypoxia and developed infrarenal AAA, which had similar morphological and pathological characteristics to human AAA. In human AAA tissue, the adventitial VV were stenotic in both small AAAs (30-49 mm in diameter) and in large AAAs (> 50 mm in diameter), with the sac tissue in these AAAs being ischemic and hypoxic. These results indicate that hypoperfusion of adventitial VV has critical effects on the development of infrarenal AAA.

Original languageEnglish
Article numbere0134386
JournalPLoS One
Volume10
Issue number8
DOIs
Publication statusPublished - 2015 Aug 26

Fingerprint

Vasa Vasorum
aneurysm
Adventitia
Abdominal Aortic Aneurysm
Tissue
Polyurethanes
Catheters
Rats
Animals
hypoxia
polyurethanes
Abdominal Aorta
sutures
aorta
catheters
Sutures
Ligation
Animal Models
animal models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Tanaka, H., Zaima, N., Sasaki, T., Sano, M., Yamamoto, N., Saito, T., ... Unno, N. (2015). Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm. PLoS One, 10(8), [e0134386]. https://doi.org/10.1371/journal.pone.0134386

Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm. / Tanaka, Hiroki; Zaima, Nobuhiro; Sasaki, Takeshi; Sano, Masaki; Yamamoto, Naoto; Saito, Takaaki; Inuzuka, Kazunori; Hayasaka, Takahiro; Goto-Inoue, Naoko; Sugiura, Yuki; Sato, Kohji; Kugo, Hirona; Moriyama, Tatsuya; Konno, Hiroyuki; Setou, Mitsutoshi; Unno, Naoki.

In: PLoS One, Vol. 10, No. 8, e0134386, 26.08.2015.

Research output: Contribution to journalArticle

Tanaka, H, Zaima, N, Sasaki, T, Sano, M, Yamamoto, N, Saito, T, Inuzuka, K, Hayasaka, T, Goto-Inoue, N, Sugiura, Y, Sato, K, Kugo, H, Moriyama, T, Konno, H, Setou, M & Unno, N 2015, 'Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm', PLoS One, vol. 10, no. 8, e0134386. https://doi.org/10.1371/journal.pone.0134386
Tanaka H, Zaima N, Sasaki T, Sano M, Yamamoto N, Saito T et al. Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm. PLoS One. 2015 Aug 26;10(8). e0134386. https://doi.org/10.1371/journal.pone.0134386
Tanaka, Hiroki ; Zaima, Nobuhiro ; Sasaki, Takeshi ; Sano, Masaki ; Yamamoto, Naoto ; Saito, Takaaki ; Inuzuka, Kazunori ; Hayasaka, Takahiro ; Goto-Inoue, Naoko ; Sugiura, Yuki ; Sato, Kohji ; Kugo, Hirona ; Moriyama, Tatsuya ; Konno, Hiroyuki ; Setou, Mitsutoshi ; Unno, Naoki. / Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm. In: PLoS One. 2015 ; Vol. 10, No. 8.
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