Hypopharyngeal squamous cell carcinoma producing both granulocyte colony-stimulating factor and parathyroid hormone-related protein

Kanae Tamura, Tomoaki Yoshinaga, Mishie Tanino, Taichi Kimura, Noriyuki Yamada, Masaharu Nishimura, Satoshi Fukuda, Hiroshi Nishihara, Masanobu Shindoh, Shinya Tanaka

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A 57-year-old woman was admitted to Hokkaido University Hospital because of dysphagia. Laryngoscopy indicated hypopharyngeal tumor histologically diagnosed as squamous cell carcinoma (SCC). A combination of radiotherapy and chemotherapy was performed for 2 months, and the hypopharyngeal lesion completely regressed. After 4 months, fever, anorexia, and malaise appeared, and chest X-ray and CT indicated two large tumors in the right lung. Transbroncheal lung biopsy (TBLB) specimens were diagnosed as SCC. Laboratory data showed high levels of serum granulocyte colony-stimulating factor (G-CSF) and parathyroid hormone-related protein (PTHrP). Subsequently, positron emission tomography (PET) showed multiple metastases to several organs including the liver, spine, skull, and thigh. Two months after readmission, the patient died with no success of chemotherapy. At autopsy, the lung tumor was clearly positive for both G-CSF and PTHrP on immunohistostaining. Retrospectively, examination showed that the primary pharyngeal tumor was focally positive for these two cytokines. Thus, a certain population of hypopharyngeal cancer producing G-CSF and PTHrP, spread to various organs and contributed to the rapid progression and poor prognosis. This case is presented with a discussion of several other cases in the literature.

Original languageEnglish
Pages (from-to)652-656
Number of pages5
JournalPathology international
Volume58
Issue number10
DOIs
Publication statusPublished - 2008 Oct
Externally publishedYes

Keywords

  • Granulocyte colony-stimulating factor
  • Hypopharynx
  • Parathyroid hormone-related protein
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Hypopharyngeal squamous cell carcinoma producing both granulocyte colony-stimulating factor and parathyroid hormone-related protein'. Together they form a unique fingerprint.

Cite this