Hypothermic temperature effects on organ survival and restoration

Jun Ishikawa, Masamitsu Oshima, Fumitaka Iwasaki, Ryoji Suzuki, Joonhong Park, Kazuhisa Nakao, Yuki Matsuzawa-Adachi, Taro Mizutsuki, Ayaka Kobayashi, Yuta Abe, Eiji Kobayashi, Katsunari Tezuka, Takashi Tsuji

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A three-dimensional multicellular organism maintains the biological functions of life support by using the blood circulation to transport oxygen and nutrients and to regulate body temperature for intracellular enzymatic reactions. Donor organ transplantation using low-temperature storage is used as the fundamental treatment for dysfunctional organs. However, this approach has a serious problem in that donor organs maintain healthy conditions only during short-term storage. In this study, we developed a novel liver perfusion culture system based on biological metabolism that can maintain physiological functions, including albumin synthesis, bile secretion and urea production. This system also allows for the resurrection of a severely ischaemic liver. This study represents a significant advance for the development of an ex vivo organ perfusion system based on biological metabolism. It can be used not only to address donor organ shortages but also as the basis of future regenerative organ replacement therapy.

Original languageEnglish
Article number9563
JournalScientific reports
Volume5
DOIs
Publication statusPublished - 2015 Apr 22

ASJC Scopus subject areas

  • General

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    Ishikawa, J., Oshima, M., Iwasaki, F., Suzuki, R., Park, J., Nakao, K., Matsuzawa-Adachi, Y., Mizutsuki, T., Kobayashi, A., Abe, Y., Kobayashi, E., Tezuka, K., & Tsuji, T. (2015). Hypothermic temperature effects on organ survival and restoration. Scientific reports, 5, [9563]. https://doi.org/10.1038/srep09563