Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina

Toshihide Kurihara, Peter D. Westenskow, Martin Friedlander

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalAdvances in experimental medicine and biology
Volume801
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Keywords

  • Age-related macular degeneration
  • Hypoxia-inducible factors
  • Retinal pigment epithelium
  • Vascular endothelial growth factor
  • Von Hippel-Lindau tumor suppressor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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