Abstract
Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.
| Original language | English |
|---|---|
| Pages (from-to) | 275-281 |
| Number of pages | 7 |
| Journal | Advances in Experimental Medicine and Biology |
| Volume | 801 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina. / Kurihara, Toshihide; Westenskow, Peter D.; Friedlander, Martin.
In: Advances in Experimental Medicine and Biology, Vol. 801, 2014, p. 275-281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina.
AU - Kurihara, Toshihide
AU - Westenskow, Peter D.
AU - Friedlander, Martin
PY - 2014
Y1 - 2014
N2 - Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.
AB - Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.
UR - http://www.scopus.com/inward/record.url?scp=84904812095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904812095&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-3209-8_35
DO - 10.1007/978-1-4614-3209-8_35
M3 - Article
C2 - 24664708
AN - SCOPUS:84904812095
VL - 801
SP - 275
EP - 281
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
SN - 0065-2598
ER -