Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina

Toshihide Kurihara; Peter D. Westenskow; Martin Friedlander

doi:10.1007/978-1-4614-3209-8_35

Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina

Toshihide Kurihara, Peter D. Westenskow, Martin Friedlander

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.

Original language	English
Pages (from-to)	275-281
Number of pages	7
Journal	Advances in experimental medicine and biology
Volume	801
DOIs	https://doi.org/10.1007/978-1-4614-3209-8_35
Publication status	Published - 2014
Externally published	Yes

Keywords

Age-related macular degeneration
Hypoxia-inducible factors
Retinal pigment epithelium
Vascular endothelial growth factor
Von Hippel-Lindau tumor suppressor

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.",

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AU - Kurihara, Toshihide

AU - Westenskow, Peter D.

AU - Friedlander, Martin

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Y1 - 2014

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AB - Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.

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KW - Hypoxia-inducible factors

KW - Retinal pigment epithelium

KW - Vascular endothelial growth factor

KW - Von Hippel-Lindau tumor suppressor

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Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina

Abstract

Keywords

ASJC Scopus subject areas

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