TY - JOUR
T1 - Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina
AU - Kurihara, Toshihide
AU - Westenskow, Peter D.
AU - Friedlander, Martin
N1 - Funding Information:
We wish to warmly thank all members of the Friedlander lab and our collaborators. Work discussed in this chapter was supported by fellowships to TK (Manpei Suzuki Diabetes Foundation and The Japan Society for the Promotion of Science Postdoctoral Fellowships for Research Abroad) and to PDW (a Ruth Kirschstein Fellow NEI EY021416). MF gratefully acknowledges the generous support of the research in our lab from the National Eye Institute of the National Institutes of Health (EY11254 and EY017540), the California Institute for Regenerative Medicine (CIRM TR1–01219), the Lowy Medical Research Foundation (the MacTel Project), and the Rasmussen Foundation.
Publisher Copyright:
© Springer Science+Business Media, LLC 2014.
PY - 2014
Y1 - 2014
N2 - Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.
AB - Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.
KW - Age-related macular degeneration
KW - Hypoxia-inducible factors
KW - Retinal pigment epithelium
KW - Vascular endothelial growth factor
KW - Von Hippel-Lindau tumor suppressor
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U2 - 10.1007/978-1-4614-3209-8_35
DO - 10.1007/978-1-4614-3209-8_35
M3 - Article
C2 - 24664708
AN - SCOPUS:84904812095
SN - 0065-2598
VL - 801
SP - 275
EP - 281
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -
