Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

Kazuki Kiyose; Kenjiro Hanaoka; Daihi Oushiki; Tomomi Nakamura; Mayumi Kajimura; Makoto Suematsu; Hiroaki Nishimatsu; Takehiro Yamane; Takuya Terai; Yasunobu Hirata; Tetsuo Nagano

doi:10.1021/ja105937q

Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

Kazuki Kiyose, Kenjiro Hanaoka, Daihi Oushiki, Tomomi Nakamura, Mayumi Kajimura, Makoto Suematsu, Hiroaki Nishimatsu, Takehiro Yamane, Takuya Terai, Yasunobu Hirata, Tetsuo Nagano

Research output: Contribution to journal › Article › peer-review

220 Citations (Scopus)

Abstract

Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

Original language	English
Pages (from-to)	15846-15848
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	45
DOIs	https://doi.org/10.1021/ja105937q
Publication status	Published - 2010 Nov 17

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja105937q

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Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia. / Kiyose, Kazuki; Hanaoka, Kenjiro; Oushiki, Daihi; Nakamura, Tomomi; Kajimura, Mayumi ; Suematsu, Makoto; Nishimatsu, Hiroaki; Yamane, Takehiro; Terai, Takuya; Hirata, Yasunobu; Nagano, Tetsuo.

In: Journal of the American Chemical Society, Vol. 132, No. 45, 17.11.2010, p. 15846-15848.

Research output: Contribution to journal › Article › peer-review

Kiyose, Kazuki ; Hanaoka, Kenjiro ; Oushiki, Daihi ; Nakamura, Tomomi ; Kajimura, Mayumi ; Suematsu, Makoto ; Nishimatsu, Hiroaki ; Yamane, Takehiro ; Terai, Takuya ; Hirata, Yasunobu ; Nagano, Tetsuo. / Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 45. pp. 15846-15848.

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AU - Nagano, Tetsuo

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