Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

Kazuki Kiyose; Kenjiro Hanaoka; Daihi Oushiki; Tomomi Nakamura; Mayumi Kajimura; Makoto Suematsu; Hiroaki Nishimatsu; Takehiro Yamane; Takuya Terai; Yasunobu Hirata; Tetsuo Nagano

doi:10.1021/ja105937q

Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

Kazuki Kiyose, Kenjiro Hanaoka, Daihi Oushiki, Tomomi Nakamura, Mayumi Kajimura, Makoto Suematsu, Hiroaki Nishimatsu, Takehiro Yamane, Takuya Terai, Yasunobu Hirata, Tetsuo Nagano

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289 Citations (Scopus)

Abstract

Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

Original language	English
Pages (from-to)	15846-15848
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	45
DOIs	https://doi.org/10.1021/ja105937q
Publication status	Published - 2010 Nov 17

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja105937q

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abstract = "Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.",

author = "Kazuki Kiyose and Kenjiro Hanaoka and Daihi Oushiki and Tomomi Nakamura and Mayumi Kajimura and Makoto Suematsu and Hiroaki Nishimatsu and Takehiro Yamane and Takuya Terai and Yasunobu Hirata and Tetsuo Nagano",

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T1 - Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

AU - Kiyose, Kazuki

AU - Hanaoka, Kenjiro

AU - Oushiki, Daihi

AU - Nakamura, Tomomi

AU - Kajimura, Mayumi

AU - Suematsu, Makoto

AU - Nishimatsu, Hiroaki

AU - Yamane, Takehiro

AU - Terai, Takuya

AU - Hirata, Yasunobu

AU - Nagano, Tetsuo

PY - 2010/11/17

Y1 - 2010/11/17

N2 - Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

AB - Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

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JF - Journal of the American Chemical Society

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Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

Abstract

ASJC Scopus subject areas

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