Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia

Kazuki Kiyose, Kenjiro Hanaoka, Daihi Oushiki, Tomomi Nakamura, Mayumi Kajimura, Makoto Suematsu, Hiroaki Nishimatsu, Takehiro Yamane, Takuya Terai, Yasunobu Hirata, Tetsuo Nagano

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207 Citations (Scopus)

Abstract

Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.

Original languageEnglish
Pages (from-to)15846-15848
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number45
DOIs
Publication statusPublished - 2010 Nov 17

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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    Kiyose, K., Hanaoka, K., Oushiki, D., Nakamura, T., Kajimura, M., Suematsu, M., Nishimatsu, H., Yamane, T., Terai, T., Hirata, Y., & Nagano, T. (2010). Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia. Journal of the American Chemical Society, 132(45), 15846-15848. https://doi.org/10.1021/ja105937q