TY - JOUR
T1 - Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA
AU - Iijima, Takatoshi
AU - Imai, Takao
AU - Kimura, Yuki
AU - Bernstein, Alan
AU - Okano, Hirotaka James
AU - Yuzaki, Michisuke
AU - Okano, Hideyuki
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/11/22
Y1 - 2005/11/22
N2 - The localization of certain mRNAs to dendrites and their local translation in synaptic regions are proposed to be involved in certain aspects of synaptic plasticity. A cis-acting element within the 3′ untranslated region (3′ UTR) of the targeted mRNAs, which is bound by a trans-acting RNA-binding protein, controls the dendritic mRNA localization. Here, we identified hematopoietic zinc finger (Hzf) as a trans-acting factor that regulates the dendritic mRNA localization of the type 1 inositol 1,4,5-trisphosphate receptor (IP3RI), a dendritically localized mRNA in cerebellar Purkinje cells, via binding to the 3′ UTR. In Hzf-deficient mice, the dendritic localization of IP3RI mRNA and brain-derived neurotrophic factor-induced IP3RI protein synthesis in the cerebellum were impaired. These findings suggest that Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of IP3RI, and may be involved in some aspects of synaptic plasticity.
AB - The localization of certain mRNAs to dendrites and their local translation in synaptic regions are proposed to be involved in certain aspects of synaptic plasticity. A cis-acting element within the 3′ untranslated region (3′ UTR) of the targeted mRNAs, which is bound by a trans-acting RNA-binding protein, controls the dendritic mRNA localization. Here, we identified hematopoietic zinc finger (Hzf) as a trans-acting factor that regulates the dendritic mRNA localization of the type 1 inositol 1,4,5-trisphosphate receptor (IP3RI), a dendritically localized mRNA in cerebellar Purkinje cells, via binding to the 3′ UTR. In Hzf-deficient mice, the dendritic localization of IP3RI mRNA and brain-derived neurotrophic factor-induced IP3RI protein synthesis in the cerebellum were impaired. These findings suggest that Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of IP3RI, and may be involved in some aspects of synaptic plasticity.
KW - 3′ UTR
KW - BDNF
KW - IPRI
KW - RNA-binding protein
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U2 - 10.1073/pnas.0504684102
DO - 10.1073/pnas.0504684102
M3 - Article
C2 - 16286649
AN - SCOPUS:28044452414
SN - 0027-8424
VL - 102
SP - 17190
EP - 17195
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 47
ER -