Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA

Takatoshi Iijima, Takao Imai, Yuki Kimura, Alan Bernstein, Hirotaka James Okano, Michisuke Yuzaki, Hideyuki Okano

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The localization of certain mRNAs to dendrites and their local translation in synaptic regions are proposed to be involved in certain aspects of synaptic plasticity. A cis-acting element within the 3′ untranslated region (3′ UTR) of the targeted mRNAs, which is bound by a trans-acting RNA-binding protein, controls the dendritic mRNA localization. Here, we identified hematopoietic zinc finger (Hzf) as a trans-acting factor that regulates the dendritic mRNA localization of the type 1 inositol 1,4,5-trisphosphate receptor (IP3RI), a dendritically localized mRNA in cerebellar Purkinje cells, via binding to the 3′ UTR. In Hzf-deficient mice, the dendritic localization of IP3RI mRNA and brain-derived neurotrophic factor-induced IP3RI protein synthesis in the cerebellum were impaired. These findings suggest that Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of IP3RI, and may be involved in some aspects of synaptic plasticity.

Original languageEnglish
Pages (from-to)17190-17195
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number47
DOIs
Publication statusPublished - 2005 Nov 22

Fingerprint

Inositol 1,4,5-Trisphosphate Receptors
Zinc Fingers
Brain-Derived Neurotrophic Factor
Messenger RNA
Proteins
Neuronal Plasticity
RNA-Binding Proteins
3' Untranslated Regions
Trans-Activators
Purkinje Cells
Dendrites
Cerebellum

Keywords

  • 3′ UTR
  • BDNF
  • IPRI
  • RNA-binding protein

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA. / Iijima, Takatoshi; Imai, Takao; Kimura, Yuki; Bernstein, Alan; Okano, Hirotaka James; Yuzaki, Michisuke; Okano, Hideyuki.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 47, 22.11.2005, p. 17190-17195.

Research output: Contribution to journalArticle

@article{f60e278b5a1e4e2980b18d7e0b75229d,
title = "Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA",
abstract = "The localization of certain mRNAs to dendrites and their local translation in synaptic regions are proposed to be involved in certain aspects of synaptic plasticity. A cis-acting element within the 3′ untranslated region (3′ UTR) of the targeted mRNAs, which is bound by a trans-acting RNA-binding protein, controls the dendritic mRNA localization. Here, we identified hematopoietic zinc finger (Hzf) as a trans-acting factor that regulates the dendritic mRNA localization of the type 1 inositol 1,4,5-trisphosphate receptor (IP3RI), a dendritically localized mRNA in cerebellar Purkinje cells, via binding to the 3′ UTR. In Hzf-deficient mice, the dendritic localization of IP3RI mRNA and brain-derived neurotrophic factor-induced IP3RI protein synthesis in the cerebellum were impaired. These findings suggest that Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of IP3RI, and may be involved in some aspects of synaptic plasticity.",
keywords = "3′ UTR, BDNF, IPRI, RNA-binding protein",
author = "Takatoshi Iijima and Takao Imai and Yuki Kimura and Alan Bernstein and Okano, {Hirotaka James} and Michisuke Yuzaki and Hideyuki Okano",
year = "2005",
month = "11",
day = "22",
doi = "10.1073/pnas.0504684102",
language = "English",
volume = "102",
pages = "17190--17195",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "47",

}

TY - JOUR

T1 - Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA

AU - Iijima, Takatoshi

AU - Imai, Takao

AU - Kimura, Yuki

AU - Bernstein, Alan

AU - Okano, Hirotaka James

AU - Yuzaki, Michisuke

AU - Okano, Hideyuki

PY - 2005/11/22

Y1 - 2005/11/22

N2 - The localization of certain mRNAs to dendrites and their local translation in synaptic regions are proposed to be involved in certain aspects of synaptic plasticity. A cis-acting element within the 3′ untranslated region (3′ UTR) of the targeted mRNAs, which is bound by a trans-acting RNA-binding protein, controls the dendritic mRNA localization. Here, we identified hematopoietic zinc finger (Hzf) as a trans-acting factor that regulates the dendritic mRNA localization of the type 1 inositol 1,4,5-trisphosphate receptor (IP3RI), a dendritically localized mRNA in cerebellar Purkinje cells, via binding to the 3′ UTR. In Hzf-deficient mice, the dendritic localization of IP3RI mRNA and brain-derived neurotrophic factor-induced IP3RI protein synthesis in the cerebellum were impaired. These findings suggest that Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of IP3RI, and may be involved in some aspects of synaptic plasticity.

AB - The localization of certain mRNAs to dendrites and their local translation in synaptic regions are proposed to be involved in certain aspects of synaptic plasticity. A cis-acting element within the 3′ untranslated region (3′ UTR) of the targeted mRNAs, which is bound by a trans-acting RNA-binding protein, controls the dendritic mRNA localization. Here, we identified hematopoietic zinc finger (Hzf) as a trans-acting factor that regulates the dendritic mRNA localization of the type 1 inositol 1,4,5-trisphosphate receptor (IP3RI), a dendritically localized mRNA in cerebellar Purkinje cells, via binding to the 3′ UTR. In Hzf-deficient mice, the dendritic localization of IP3RI mRNA and brain-derived neurotrophic factor-induced IP3RI protein synthesis in the cerebellum were impaired. These findings suggest that Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of IP3RI, and may be involved in some aspects of synaptic plasticity.

KW - 3′ UTR

KW - BDNF

KW - IPRI

KW - RNA-binding protein

UR - http://www.scopus.com/inward/record.url?scp=28044452414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28044452414&partnerID=8YFLogxK

U2 - 10.1073/pnas.0504684102

DO - 10.1073/pnas.0504684102

M3 - Article

C2 - 16286649

AN - SCOPUS:28044452414

VL - 102

SP - 17190

EP - 17195

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 47

ER -