Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA

Takatoshi Iijima, Takao Imai, Yuki Kimura, Alan Bernstein, Hirotaka James Okano, Michisuke Yuzaki, Hideyuki Okano

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The localization of certain mRNAs to dendrites and their local translation in synaptic regions are proposed to be involved in certain aspects of synaptic plasticity. A cis-acting element within the 3′ untranslated region (3′ UTR) of the targeted mRNAs, which is bound by a trans-acting RNA-binding protein, controls the dendritic mRNA localization. Here, we identified hematopoietic zinc finger (Hzf) as a trans-acting factor that regulates the dendritic mRNA localization of the type 1 inositol 1,4,5-trisphosphate receptor (IP3RI), a dendritically localized mRNA in cerebellar Purkinje cells, via binding to the 3′ UTR. In Hzf-deficient mice, the dendritic localization of IP3RI mRNA and brain-derived neurotrophic factor-induced IP3RI protein synthesis in the cerebellum were impaired. These findings suggest that Hzf is an RNA-binding protein that controls the dendritic mRNA localization and activity-dependent translation of IP3RI, and may be involved in some aspects of synaptic plasticity.

Original languageEnglish
Pages (from-to)17190-17195
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number47
DOIs
Publication statusPublished - 2005 Nov 22

Keywords

  • 3′ UTR
  • BDNF
  • IPRI
  • RNA-binding protein

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA'. Together they form a unique fingerprint.

Cite this