Identification and characterization of mouse type II platelet-derived growth factor receptor α transcript

Yusuke Minato, Yoshiaki Nihei, Yuki Kodama, Etsu Tashiro, Mai Kanai, Masaya Imoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor α mRNA (type II) that differs from the known human PDGF receptor α mRNA (type I) only in its 5′-untranslated region and is regulated by E2F-1. In this study, we determined the nucleotide sequence of the mouse type II PDGF receptor α mRNA and found that the expression of this transcript was regulated by E2F-1 through an E2F-1-responsive sequence located +711/+718 downstream of the transcription start site of the type I transcript. Furthermore, we observed embryo-predominant expression of the type II transcript.

Original languageEnglish
Pages (from-to)759-766
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number3
DOIs
Publication statusPublished - 2008

Fingerprint

Platelet-Derived Growth Factor Receptors
Platelets
Messenger RNA
mice
5' Untranslated Regions
Transcription Initiation Site
5' untranslated regions
Transcription
Nucleotides
embryo (animal)
Embryonic Structures
transcription (genetics)
nucleotide sequences
Intercellular Signaling Peptides and Proteins
platelet-derived growth factor receptors

Keywords

  • Alternate promoter
  • E2F-1
  • Platelet-derived growth factor receptor α
  • Transcript variant
  • Transcriptional regulation

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Food Science

Cite this

Identification and characterization of mouse type II platelet-derived growth factor receptor α transcript. / Minato, Yusuke; Nihei, Yoshiaki; Kodama, Yuki; Tashiro, Etsu; Kanai, Mai; Imoto, Masaya.

In: Bioscience, Biotechnology and Biochemistry, Vol. 72, No. 3, 2008, p. 759-766.

Research output: Contribution to journalArticle

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