Identification and characterization of mouse type II platelet-derived growth factor receptor α transcript

Yusuke Minato, Yoshiaki Nihei, Yuki Kodama, Etsu Tashiro, Mai Kanai, Masaya Imoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor α mRNA (type II) that differs from the known human PDGF receptor α mRNA (type I) only in its 5′-untranslated region and is regulated by E2F-1. In this study, we determined the nucleotide sequence of the mouse type II PDGF receptor α mRNA and found that the expression of this transcript was regulated by E2F-1 through an E2F-1-responsive sequence located +711/+718 downstream of the transcription start site of the type I transcript. Furthermore, we observed embryo-predominant expression of the type II transcript.

Original languageEnglish
Pages (from-to)759-766
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number3
DOIs
Publication statusPublished - 2008 Apr 7

Keywords

  • Alternate promoter
  • E2F-1
  • Platelet-derived growth factor receptor α
  • Transcript variant
  • Transcriptional regulation

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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