Identification and characterization of mouse type II platelet-derived growth factor receptor α transcript

Yusuke Minato; Yoshiaki Nihei; Yuki Kodama; Etsu Tashiro; Mai Kanai; Masaya Imoto

doi:10.1271/bbb.70640

Identification and characterization of mouse type II platelet-derived growth factor receptor α transcript

Yusuke Minato, Yoshiaki Nihei, Yuki Kodama, Etsu Tashiro, Mai Kanai, Masaya Imoto

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor α mRNA (type II) that differs from the known human PDGF receptor α mRNA (type I) only in its 5′-untranslated region and is regulated by E2F-1. In this study, we determined the nucleotide sequence of the mouse type II PDGF receptor α mRNA and found that the expression of this transcript was regulated by E2F-1 through an E2F-1-responsive sequence located +711/+718 downstream of the transcription start site of the type I transcript. Furthermore, we observed embryo-predominant expression of the type II transcript.

Original language	English
Pages (from-to)	759-766
Number of pages	8
Journal	Bioscience, Biotechnology and Biochemistry
Volume	72
Issue number	3
DOIs	https://doi.org/10.1271/bbb.70640
Publication status	Published - 2008
Externally published	Yes

Keywords

Alternate promoter
E2F-1
Platelet-derived growth factor receptor α
Transcript variant
Transcriptional regulation

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "Identification and characterization of mouse type II platelet-derived growth factor receptor α transcript",

abstract = "Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor α mRNA (type II) that differs from the known human PDGF receptor α mRNA (type I) only in its 5′-untranslated region and is regulated by E2F-1. In this study, we determined the nucleotide sequence of the mouse type II PDGF receptor α mRNA and found that the expression of this transcript was regulated by E2F-1 through an E2F-1-responsive sequence located +711/+718 downstream of the transcription start site of the type I transcript. Furthermore, we observed embryo-predominant expression of the type II transcript.",

keywords = "Alternate promoter, E2F-1, Platelet-derived growth factor receptor α, Transcript variant, Transcriptional regulation",

author = "Yusuke Minato and Yoshiaki Nihei and Yuki Kodama and Etsu Tashiro and Mai Kanai and Masaya Imoto",

note = "Funding Information: This work was partly supported by a Grant-in-Aid for JSPS Fellows and Young Scientists (B) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, a grant from the Takeda Science Foundation, and a grant from Special Coordination Funds to Promote Science and Technology from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.",

year = "2008",

doi = "10.1271/bbb.70640",

language = "English",

volume = "72",

pages = "759--766",

journal = "Bioscience, Biotechnology and Biochemistry",

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publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

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T1 - Identification and characterization of mouse type II platelet-derived growth factor receptor α transcript

AU - Minato, Yusuke

AU - Nihei, Yoshiaki

AU - Kodama, Yuki

AU - Tashiro, Etsu

AU - Kanai, Mai

AU - Imoto, Masaya

N1 - Funding Information: This work was partly supported by a Grant-in-Aid for JSPS Fellows and Young Scientists (B) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, a grant from the Takeda Science Foundation, and a grant from Special Coordination Funds to Promote Science and Technology from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

PY - 2008

Y1 - 2008

N2 - Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor α mRNA (type II) that differs from the known human PDGF receptor α mRNA (type I) only in its 5′-untranslated region and is regulated by E2F-1. In this study, we determined the nucleotide sequence of the mouse type II PDGF receptor α mRNA and found that the expression of this transcript was regulated by E2F-1 through an E2F-1-responsive sequence located +711/+718 downstream of the transcription start site of the type I transcript. Furthermore, we observed embryo-predominant expression of the type II transcript.

AB - Recently, we identified a novel human platelet-derived growth factor (PDGF) receptor α mRNA (type II) that differs from the known human PDGF receptor α mRNA (type I) only in its 5′-untranslated region and is regulated by E2F-1. In this study, we determined the nucleotide sequence of the mouse type II PDGF receptor α mRNA and found that the expression of this transcript was regulated by E2F-1 through an E2F-1-responsive sequence located +711/+718 downstream of the transcription start site of the type I transcript. Furthermore, we observed embryo-predominant expression of the type II transcript.

KW - Alternate promoter

KW - E2F-1

KW - Platelet-derived growth factor receptor α

KW - Transcript variant

KW - Transcriptional regulation

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SN - 0916-8451

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 3

ER -

Identification and characterization of mouse type II platelet-derived growth factor receptor α transcript

Abstract

Keywords

ASJC Scopus subject areas

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