Identification of 27-Nor-3a, 7α, 12α-Trihydroxycoprostan-24-One Apparently Derived from 3α, 7α, 12α-Trihydroxy-24-Oxocoprostanoic Acid, A Postulated Intermediate of Bile Acid Biosynthesis

Masatoshi Yuri, Marie Tokumoto, Noriyuki Hara, Yoshinori Fujimoto, Noriko Kobayashi, Masuo Morisaki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Incubation of [27-13C]-3a,7a,12a-trihydroxycoprost-24-en-26-oic acid with rat liver homogenate followed by l3C-NMR analysis of the incubation product has resulted in the identification of [26-13C]-27-nor-3a,7a,12a-trihydroxycoprostan-24-one, supporting the idea that the substrate has been metabolized into 3a,7a,12a-trihydroxy-24-oxocoprostan-26-oic acid CoA derivative.

Original languageEnglish
Pages (from-to)1327-1329
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume41
Issue number7
DOIs
Publication statusPublished - 1993 Jan 1

Keywords

  • 13C-label
  • 27-nor-3α,7α,12α-trihydroxycoprostan-24-one
  • cholic acid 3α,7α,12α-trihydroxycoprost-24-en-26-oic acid
  • β-oxidation

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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