Identification of a human papillomavirus type 58 lineage in multiple Bowen's disease on the fingers: Case report and published work review

Kenta Kobayashi, Keiji Tanese, Akiharu Kubo, Naoko Matsumoto-Mochimaru, Aya Sasaki, Kaori Kameyama, Masayuki Amagai, Noriko Umegaki

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Human papillomavirus (HPV) has been detected in some cases of Bowen's disease, particularly on the fingers and genitalia. HPV-58 is classified as a high-risk mucosal type and accounts for a high percentage of cervical cancer in Asia. Moreover, several HPV-58 lineages, including sublineage A1, have a high prevalence in Asia. However, the nature of HPV-58-associated skin cancer is still unknown. Here, we report a case of a Japanese patient with multiple Bowen's disease on the fingers. A 33-year-old man presented with multiple reddish-brown scaly plaques on his left middle finger and right ring finger. All lesions were surgically excised, and the diagnosis of Bowen's disease was made. We performed Sanger sequencing using DNA extracted from paraffin-embedded samples and identified HPV-58 sublineage A1. Additionally, we review previous reports on HPV-58-associated skin cancers, including our case, showing a high regional prevalence in Asia. Further studies would be needed to reveal the relationship between HPV-58 lineages and carcinogenesis in the skin.

Original languageEnglish
JournalJournal of Dermatology
Publication statusAccepted/In press - 2018 Jan 1



  • Asia
  • Bowen's disease
  • DNA sequencing
  • Human papillomavirus
  • Human papillomavirus type 58

ASJC Scopus subject areas

  • Dermatology

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