Identification of a member of the MAPKKK family as a potential Mediator of TGF-β signal transduction

Kyoko Yamaguchi, Kyoko Shirakabe, Hiroshi Shibuya, Kenji Irie, Isao Oishi, Naoto Ueno, Tadatsugu Taniguchi, Eisuke Nishida, Kunihiro Matsumoto

Research output: Contribution to journalArticle

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Abstract

The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs, MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK), A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family, TAK1 was shown to participate in regulation of transcription by transforming growth factor-β (TGF-β), Furthermore, kinase activity of TAK1 was stimulated in response to TGF-β and bone morphogenetic protein, These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-β superfamily members.

Original languageEnglish
Pages (from-to)2008-2011
Number of pages4
JournalScience
Volume270
Issue number5244
Publication statusPublished - 1995 Dec 22

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Mitogen-Activated Protein Kinase Kinases
Transforming Growth Factors
Mitogen-Activated Protein Kinases
Signal Transduction
Phosphotransferases
Bone Morphogenetic Proteins
Genetic Selection
Protein Kinases
Yeasts
Phosphorylation

ASJC Scopus subject areas

  • General

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Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., ... Matsumoto, K. (1995). Identification of a member of the MAPKKK family as a potential Mediator of TGF-β signal transduction. Science, 270(5244), 2008-2011.

Identification of a member of the MAPKKK family as a potential Mediator of TGF-β signal transduction. / Yamaguchi, Kyoko; Shirakabe, Kyoko; Shibuya, Hiroshi; Irie, Kenji; Oishi, Isao; Ueno, Naoto; Taniguchi, Tadatsugu; Nishida, Eisuke; Matsumoto, Kunihiro.

In: Science, Vol. 270, No. 5244, 22.12.1995, p. 2008-2011.

Research output: Contribution to journalArticle

Yamaguchi, K, Shirakabe, K, Shibuya, H, Irie, K, Oishi, I, Ueno, N, Taniguchi, T, Nishida, E & Matsumoto, K 1995, 'Identification of a member of the MAPKKK family as a potential Mediator of TGF-β signal transduction', Science, vol. 270, no. 5244, pp. 2008-2011.
Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N et al. Identification of a member of the MAPKKK family as a potential Mediator of TGF-β signal transduction. Science. 1995 Dec 22;270(5244):2008-2011.
Yamaguchi, Kyoko ; Shirakabe, Kyoko ; Shibuya, Hiroshi ; Irie, Kenji ; Oishi, Isao ; Ueno, Naoto ; Taniguchi, Tadatsugu ; Nishida, Eisuke ; Matsumoto, Kunihiro. / Identification of a member of the MAPKKK family as a potential Mediator of TGF-β signal transduction. In: Science. 1995 ; Vol. 270, No. 5244. pp. 2008-2011.
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