Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction

Kyoko Yamaguchi, Kyoko Shirakabe, Hiroshi Shibuya, Kenji Irie, Isao Oishi, Naoto Ueno, Tadatsugu Taniguchi, Eisuke Nishida, Kunihiro Matsumoto

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Abstract

The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. was shown to participate in regulation of transcription by transforming growth factor-β (TGF-β). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-β and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-β superfamily members.

Original languageEnglish
Pages (from-to)2008-2011
Number of pages4
JournalScience
Volume270
Issue number5244
DOIs
Publication statusPublished - 1995 Jan 1

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Cite this

Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T., Nishida, E., & Matsumoto, K. (1995). Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science, 270(5244), 2008-2011. https://doi.org/10.1126/science.270.5244.2008