Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages

Arihiro Iwasaki; Osamu Ohno; Shun Katsuyama; Maho Morita; Yukiko Sasazawa; Shingo Dan; Siro Simizu; Takao Yamori; Kiyotake Suenaga

doi:10.1016/j.bmcl.2015.09.044

Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages

Arihiro Iwasaki, Osamu Ohno, Shun Katsuyama, Maho Morita, Yukiko Sasazawa, Shingo Dan, Siro Simizu, Takao Yamori, Kiyotake Suenaga

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

In 2014, we isolated kurahyne, an acetylene-containing lipopeptide, from a marine cyanobacterial assemblage of Lyngbya sp. Kurahyne exhibited growth-inhibitory activity against human cancer cells, and induced apoptosis in HeLa cells. However, its mode of action is not yet clear. To elucidate its mode of action, we carried out several cell-based assays, and identified the intracellular target molecule of kurahyne as sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA). In addition, we found that kurahyne inhibited the differentiation of macrophages into osteoclasts.

Original language	English
Pages (from-to)	5295-5298
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2015.09.044
Publication status	Published - 2015 Nov 15

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Keywords

Apoptosis
ER stress
Kurahyne
Marine natural product
SERCA

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Molecular Biology
Molecular Medicine
Organic Chemistry
Drug Discovery
Pharmaceutical Science

Cite this

Iwasaki, A., Ohno, O., Katsuyama, S., Morita, M., Sasazawa, Y., Dan, S., Simizu, S., Yamori, T., & Suenaga, K. (2015). Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages. Bioorganic and Medicinal Chemistry Letters, 25(22), 5295-5298. https://doi.org/10.1016/j.bmcl.2015.09.044

Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages. / Iwasaki, Arihiro; Ohno, Osamu; Katsuyama, Shun; Morita, Maho; Sasazawa, Yukiko; Dan, Shingo; Simizu, Siro; Yamori, Takao; Suenaga, Kiyotake.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 25, No. 22, 15.11.2015, p. 5295-5298.

Research output: Contribution to journal › Article

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10.1016/j.bmcl.2015.09.044