Abstract
In 2014, we isolated kurahyne, an acetylene-containing lipopeptide, from a marine cyanobacterial assemblage of Lyngbya sp. Kurahyne exhibited growth-inhibitory activity against human cancer cells, and induced apoptosis in HeLa cells. However, its mode of action is not yet clear. To elucidate its mode of action, we carried out several cell-based assays, and identified the intracellular target molecule of kurahyne as sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). In addition, we found that kurahyne inhibited the differentiation of macrophages into osteoclasts.
| Original language | English |
|---|---|
| Pages (from-to) | 5295-5298 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 25 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - 2015 Nov 15 |
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Keywords
- Apoptosis
- ER stress
- Kurahyne
- Marine natural product
- SERCA
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Molecular Biology
- Molecular Medicine
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages. / Iwasaki, Arihiro; Ohno, Osamu; Katsuyama, Shun; Morita, Maho; Sasazawa, Yukiko; Dan, Shingo; Simizu, Siro; Yamori, Takao; Suenaga, Kiyotake.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 25, No. 22, 15.11.2015, p. 5295-5298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages
AU - Iwasaki, Arihiro
AU - Ohno, Osamu
AU - Katsuyama, Shun
AU - Morita, Maho
AU - Sasazawa, Yukiko
AU - Dan, Shingo
AU - Simizu, Siro
AU - Yamori, Takao
AU - Suenaga, Kiyotake
PY - 2015/11/15
Y1 - 2015/11/15
N2 - In 2014, we isolated kurahyne, an acetylene-containing lipopeptide, from a marine cyanobacterial assemblage of Lyngbya sp. Kurahyne exhibited growth-inhibitory activity against human cancer cells, and induced apoptosis in HeLa cells. However, its mode of action is not yet clear. To elucidate its mode of action, we carried out several cell-based assays, and identified the intracellular target molecule of kurahyne as sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). In addition, we found that kurahyne inhibited the differentiation of macrophages into osteoclasts.
AB - In 2014, we isolated kurahyne, an acetylene-containing lipopeptide, from a marine cyanobacterial assemblage of Lyngbya sp. Kurahyne exhibited growth-inhibitory activity against human cancer cells, and induced apoptosis in HeLa cells. However, its mode of action is not yet clear. To elucidate its mode of action, we carried out several cell-based assays, and identified the intracellular target molecule of kurahyne as sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). In addition, we found that kurahyne inhibited the differentiation of macrophages into osteoclasts.
KW - Apoptosis
KW - ER stress
KW - Kurahyne
KW - Marine natural product
KW - SERCA
UR - http://www.scopus.com/inward/record.url?scp=84945931562&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945931562&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2015.09.044
DO - 10.1016/j.bmcl.2015.09.044
M3 - Article
C2 - 26428873
AN - SCOPUS:84945931562
VL - 25
SP - 5295
EP - 5298
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 22
ER -